Results 211 to 220 of about 563,981 (384)
MicroRNA-142-5p (miRNA-142-5p); miRNA-155; miRNA-223; miRNA-10b; miRNA-30a-3p [PDF]
Science-Business eXchange, 2009 openaire +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Advanced Science, EarlyView.A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang +7 more
wiley +1 more source
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, EarlyView.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.By integrating biomechanical and epigenetic cues, the evolutionarily conserved TPM1 super‐enhancer drives myogenesis via TEAD4‐mediated chromatin looping. This mechanism produces species‐specific outputs (linear TPM1 mRNA in mice and CircTPM1 in bovine) that activate PI3K/AKT mechanotransduction and the MYH10/MYL3 axis to execute cytoskeletal ...
Ruimen Zhang +27 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang +10 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen +4 more
wiley +1 more source