Results 141 to 150 of about 151,150 (352)

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1485-1489, April 2025.
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Sanjay Divakaran, Vinay Randhawa, Usman A. Tahir, Matthew Robertson, Anam A. Waheed, Anna Perillo, Leanne Barrett, Ron Blankstein, Mark W. Feinberg, Marcelo F. Di Carli, Neal K. Lakdawala   +10 more
wiley   +1 more source

Spina bifida and anencephaly: miscarriage as possible cause. [PDF]

, 1975
Christine L. Clarke, D. Hobson, O. McKendrick, Stephen Rogers, P. M. Sheppard   +4 more
openalex   +1 more source

Homocysteine And Recurrent Miscarriage

The Moldovan Medical Journal, 2017
Background: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine.
openaire   +6 more sources

Knowledge, Prevalence and Psychological Effect of Miscarriage among women of reproductive age group attending Obstetrics and Gynaecology Clinics of Lagos University Teaching Hospital, Nigeria

Nigerian Postgraduate Medical Journal, 2013
Aims and objectives: To determine the knowledge, prevalence and psychological effect of miscarriage among women of reproductive age attending the obstetrics and gynaecology clinics of a tertiary healthcare facility in Lagos Nigeria. Materials and methods:
A O Abiola, A Ajayi, C S Umeh, M O Adegbesan-Omilabu, T F Olufunlayo, B A Akodu   +5 more
doaj  

State of precision medicine for heart failure with preserved ejection fraction in a new therapeutic age

ESC Heart Failure, Volume 12, Issue 3, Page 1544-1557, June 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous pathophysiology with multiple co‐morbidities contributing to its presentation. Establishing the diagnosis of HFpEF can be challenging.
Roy Rasalam, Andrew Sindone, Gary Deed, Ralph G. Audehm, John J. Atherton   +4 more
wiley   +1 more source

A Generalized Mixture Cure Model Incorporating Known Cured Individuals [PDF]

arXiv
The Mixture Cure (MC) models constitute an appropriate and easily interpretable method when studying a time-to-event variable in a population comprised of both susceptible and cured individuals. In literature, those models usually assume that the latter are unobservable. However, there are cases in which a cured individual may be identified.
arxiv  

Miscarriages as a cause of spina bifida and anencephaly. [PDF]

, 1977
D I Rushton
openalex   +1 more source

Cardiac magnetic resonance left atrioventricular coupling index as a prognostic tool in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 3, Page 2177-2189, June 2025.
Abstract Aims A novel marker left atrioventricular coupling index (LACI) has been proved to be associated with cardiovascular events in patients without history of cardiovascular disease. However, the studies on cardiac magnetic resonance‐derived LACI in hypertrophic cardiomyopathy (HCM) patients are limited, and the prognostic value of LACI has still ...
Jinyang Wen, Junhao Tu, Xinwei Tao, Yuanyuan Tang, Zhaoxia Yang, Ziyi Pan, Yi Luo, Chunlin Xiang, Dazhong Tang, Lu Huang, Liming Xia   +10 more
wiley   +1 more source

Genetic evolution of a multi-generational population in the context of interstellar space travels -- Part II: Phenotypic effects of gene expression [PDF]

arXiv
In the first paper of this series, we included the effects of population genetics in the agent-based Monte Carlo code HERITAGE under the hypothesis of neutral phenotypic effects. It implied that mutations (genetic changes) had only neutral physical manifestations.
arxiv