Results 111 to 120 of about 18,660 (261)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Redress and civil litigation report [PDF]
, 2015 The Royal Commission has examined the extent to which ‘justice for victims’ of institutional child abuse has been, or can be, achieved through previous and current redress processes and civil litigation systems.
Royal Commission into Institutional Responses to Child Sexual Abuse
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Nutrition and nitrogen-fixation in Malaysian Pterocarpus Indicus willd [PDF]
, 2011 Pterocarpus indicus is a promising tropical woody legume for the establishment of forest plantations in Malaysia. Woody legumes that form symbiotic relationships with nitrogen-fixing bacteria also play an important role for forest restoration on degraded
Lok, Eng Hai
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
(A) study on classification systems of infectious wastes
, 2004 환경보건학과/석사[한글] 전국민 의료보장제도의 확대 실시에 따라 의료기관의 이용률은 증가하여 사람의 평균 수명은 예전보다 증가하였으나, 의료활동으로 인해 부수적으로 감염성폐기물이 양산되었고 감염성폐기물은 질병과 관련된 의료 및 연구과정 등에서 발생되기 때문에 병원성 세균류가 존재하여 전염성이 강하고 질병유발 바이러스들을 공존하고 있어 2차 오염으로 인한 잠재적인 위험성이 매우 커 특별한 주의와 관심이 집중되고 있다.
김수찬
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source