Results 91 to 100 of about 18,660 (261)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Weiterentwicklung der Endoskopischen Mikrochirurgie Schlussbericht
, 1993 Since 1980 we worked on the development of Minimal Invasive Surgery. After the introduction of Transanal Endoscopic Microsurgery (TEM) into clinical practise in 1984, as the first endoscopic surgical method, the emphasis of our investigation was put on ...
Mentges, B. +3 more
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The potential future role of antiviral fabrics within healthcare systems
Health care-associated infection is acquired by patients while receiving care and represents the most frequent adverse event with a prevalence internationally ranging from 5.7% to 19.1%.
Forrester-Soto, Naomi +2 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Carbon, litter and soil fertility in monoculture and silvopastoral systems
Silvopastoral systems are an alternative for the recovery of degraded pastures. Therefore, the objective of this study was to evaluate the litterfall input and decomposition, the increase in nutrient levels, and the C and N stock in the soil in different
Coelho, Marino Salgarello
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Herstellung supraleitender Schichten mittels Plasmaspritzen und Vakuumspritzen Abschlussbericht
, 1991 Within the scope of this work it is the objective to find working conditions for the plasma spray processing of high temperature superconducting systems La-Sr-Cu-O, Y-Ba-Cu-O and Bi-Sr-Ca-Cu-O.
Lugscheider, E. +1 more
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