Results 71 to 80 of about 71,839 (258)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Decoding the integrated approach to yoga therapy: Qualitative evidence based conceptual framework

International Journal of Yoga, 2014
Aim: The aim of this study was to define, decode, and append to the conceptual frame-work of the integrated approach to yoga therapy (IAYT). Materials and Methods: Four stakeholders who followed two in-patients with depression over a period of 2 weeks in
Maria Del Carmen Villacres, Aarti Jagannathan, R Nagarathna, Jayashree Ramakrsihna   +3 more
doaj   +1 more source

The Economics of Rotational Grazing in the Gulf Coast Region: Costs, Returns, and Labor Considerations, Phase II [PDF]

Profitability and labor associated with rotational grazing at three stocking rates and continuous grazing at a medium stocking rate are compared. On a per-acre basis, profits are lowest for low stocking rate rotational grazing.
Blouin, David, Boucher, Robert W., Gillespie, Jeffrey M., Nipper, Weldon, Qushim, Berdikul, Venuto, Brad, Wyatt, Wayne   +6 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of Bhramari Pranayama on response inhibition: Evidence from the stop signal task

International Journal of Yoga, 2014
Context: Response inhibition is a key executive control processes. An inability to inhibit inappropriate actions has been linked to a large range of neurologic and neuropsychiatric disorders.
Sasidharan K Rajesh, Judu V Ilavarasu, Thaiyar M Srinivasan   +2 more
doaj   +1 more source

Technologies for restricting mould growth on baled silage [PDF]

, 2007
End of project reportSilage is made on approximately 86% of Irish farms, and 85% of these make some baled silage. Baled silage is particularly important as the primary silage making, storage and feeding system on many beef and smaller sized farms, but is
Clipson, Nicholas J.W., Doohan, Fiona, Doyle, Evelyn M., Egan, Damian, Forristal, Dermot, Frisvad, Jens C., Fuller, Hubert T., Laffin, Christopher, McEniry, Joseph, McNally, Gerard M., Nielsen, Kristian F., O'Brien, Martin, O'Kiely, Padraig, Small, Christopher M.   +13 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source