Results 71 to 80 of about 18,660 (261)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 1992 The objectives of the present research are to investigate formation of monolithic as well as composite and alloy oxide coatings on non-oxide ceramics, using the electrochemical coating method.
Steinbrech, R.N. (Forschungszentrum Juelich GmbH (Germany)) +3 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Integrative Medicine Research, 2013 Background: The purpose of this study is to examine the effects of different eating times on blood circulation index, pulse wave energy (E), and radial augmentation index (RAI) of healthy adult men.
Gyeong-Cheol Kim +3 more
doaj +1 more source
, 2003 In the event of a nuclear accident affecting the UK, regulation of contamination in the foodchain would involve both the Food Standards Agency (FSA) and the Environment Agency (EA).
National Radiological Protection Board (United Kingdom) +1 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Role of red grape polyphenols as antidiabetic agents
Integrative Medicine Research, 2014 The worldwide incidence of diabetes mellitus has reached alarming proportions. Persistent hyperglycemia due to impaired insulin activity and/or insulin resistance inversely affects the retina, cerebrovascular system, kidney, peripheral limbs, and other ...
Kanti Bhooshan Pandey +1 more
doaj +1 more source
Gelatin Nanocarriers as Biocompatible Platforms for Targeted Drug Delivery in Cancer Therapy
Introduction: Innovative drug delivery systems are required to improve the therapeutic efficacy of cancer, which continues to be a global health challenge.
Vikas Aggarwal +6 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source