Results 121 to 130 of about 75,905 (309)

Curcuma xanthorrhiza extract and xanthorrhizol ameliorate cancer-induced adipose wasting in CT26-bearing mice by regulating lipid metabolism and adipose tissue browning

Integrative Medicine Research
Background: Cancer cachexia—characterized by anorexia, body weight loss, skeletal muscle atrophy, and fat loss—affects nearly 80% of cancer patients and accounts for 20% of cancer deaths.
Haeun Kim, Dong-Woo Lee, Jae-Kwan Hwang
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Effectiveness and safety of acupuncture for carpal tunnel syndrome: An overview of systematic reviews and meta-analyses

Integrative Medicine Research
Background: Several systematic reviews (SRs) and meta-analyses (MAs) have explored the effectiveness and safety of acupuncture for Carpal Tunnel Syndrome (CTS), but findings are inconsistent and vary in quality.
Yulin Liu, Chao Wang, Qi Wang, Qing Zhang, Songhao Ning, Quanai Zhang   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Canadian Elder Standard - Pricing the Cost of Basic Needs for the Canadian Elderly [PDF]

We determined the after-tax income required to fi nance basic needs for Canadian elders living with different circumstances in terms of age, gender, city of residence, household size, homeowner or renter status, means of transportation, and health status.
Bonnie-Jeanne MacDonald, Doug Andrews, Robert L. Brown   +2 more
core  

The Beck Initiative : training school-based mental health staff in cognitive therapy [PDF]

, 2013
A growing literature supports cognitive therapy (CT) as an efficacious treatment for youth struggling with emotional or behavioral problems. Recently, work in this area has extended the dissemination of CT to school-based settings.
Beck, Aaron T., Creed, Torrey A., Evans, Arthur, Feinberg, Betsy, Hurford, Matthew O., Jager-Hyman, Shari, Pontoski, Kristin, Rosenberg, Zachary   +7 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

That's the way to go: Attached to successful publication of BMJ acupuncture collection “Acupuncture: How to improve the evidence base”

Integrative Medicine Research, 2022
Tae-Hun Kim, Myeong Soo Lee, Stephen Birch, Terje Alraek   +3 more
doaj   +1 more source

Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults. [PDF]

, 2019
Adverse drug reactions (ADRs) contribute to hospitalization but data on its economic burden is scant. Pre-emptive pharmacogenetic (PGx) testing can potentially reduce ADRs and its associated costs.
Brunham, Liam R, Chan, Alexandre, Chan, Sze Ling, Ng, Hong Yen, Sung, Cynthia, Wee, Hwee-Lin, Winther, Michael D   +6 more
core   +1 more source

Reporting an Experience on Design and Implementation of e-Health Systems on Azure Cloud

, 2013
Electronic Health (e-Health) technology has brought the world with significant transformation from traditional paper-based medical practice to Information and Communication Technologies (ICT)-based systems for automatic management (storage, processing ...
A. Eman, G. Chamara, G. Sukanta, L.A.U. Holzle, S. Nepal   +4 more
core   +1 more source