Results 21 to 30 of about 95,914 (208)
Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity [PDF]
, 2015 Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are ...
Andrade-Navarro, Miguel A. +24 more
core +2 more sources
Sequential storage and release of microdroplets
Microsystems & Nanoengineering, 2021 Droplet microfluidic methods have opened up the possibility of studying a plethora of phenomena ranging from biological to physical or chemical processes at ultra low volumes and high throughput.
Zenon Toprakcioglu, Tuomas P. J. Knowles
doaj +1 more source
β-Cell failure in type 2 diabetes: a case of asking too much of too few? [PDF]
, 2013 The islet in type 2 diabetes (T2DM) is characterized by a deficit in β-cells, increased β-cell apoptosis, and extracellular amyloid deposits derived from islet amyloid polypeptide (IAPP). In the absence of longitudinal studies, it is unknown if the low β-
Butler, Peter C +4 more
core +1 more source
The stress of misfolding [PDF]
Nature Reviews Drug Discovery, 2012 Endoplasmic reticulum stress influences neurodegeneration in a mouse model of α-synucleinopathy.
openaire +2 more sources
Nature Communications, 2019 Transient oligomeric species of the amyloid-β peptide (Aβ42) have been identified as key pathogenic agents in Alzheimer’s disease. Here the authors find that the aminosterol trodusquemine enhances Aβ42 aggregation and suppresses Aβ42-induced toxicity by ...
Ryan Limbocker +24 more
doaj +1 more source
Automated optimisation of solubility and conformational stability of antibodies and proteins
Nature Communications, 2023 Antibodies find key applications in research, diagnostics, and therapeutics, but their development can be impeded by poor stability or solubility. Here the authors developed a computational strategy that enables antibody optimisation, without affecting ...
Angelo Rosace +7 more
doaj +1 more source
Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]
, 2008 Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano +8 more
core +3 more sources
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels
Scientific Reports, 2021 Microcapsules and microgels consisting of macromolecular networks have received increasing attention due to their biomedical and pharmaceutical applications.
Zenon Toprakcioglu, Tuomas P. J. Knowles
doaj +1 more source
Spatially non-uniform condensates emerge from dynamically arrested phase separation
Nature Communications, 2023 Biomolecular condensates with internal structure allow cells to further organise their processes. In this work the authors investigate how condensates can obtain an internal structure with droplets of dilute phase inside via kinetic, rather than purely ...
Nadia A. Erkamp +9 more
doaj +1 more source
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles
Frontiers in Neuroscience, 2020 α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson’s disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a role in the trafficking ...
Wing K. Man +5 more
doaj +1 more source