Results 71 to 80 of about 67,006 (289)

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

FANCD2 counteracts O6-methylguanine-induced mismatch repair-dependent apoptosis [PDF]

福岡歯科大学博士（歯学）2024年度Background: Sn1-type alkylating agents methylate the oxygen atom on guanine bases thereby producing O6-methylguanine. This modified base could pair with thymine and cytosine, resulting in the formation of O6-methylguanine/thymine ...
Uechi, Yuka, 松浦, 尚志, Fujikane, Ryosuke, Hidaka, Masumi, 森田, 祥, 日髙, 真純, 上地, 有香, Sho, Morita, 藤兼, 亮輔, Matsuura, Takashi   +9 more
core   +2 more sources

Nanopore strand-specific mismatch enables de novo detection of bacterial DNA modifications

Genome Research
DNA modifications in bacteria present diverse types and distributions, playing crucial functional roles. Current methods for detecting bacterial DNA modifications via nanopore sequencing typically involve comparing raw current signals to a methylation-free control. In this study, we found that bacterial DNA modification induces errors in nanopore reads.
Xudong Liu, Ying Ni, Lianwei Ye, Zhihao Guo, Lu Tan, Jun Li, Mengsu Yang, Sheng Chen, Runsheng Li   +8 more
openaire   +2 more sources

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

The methyltransferase N6amt1 regulates hippocampal neurogenesis through 6 mA modification of Txnrd3 DNA

Cellular and Molecular Life Sciences
N6-methyladenine (6 mA), the most prevalent DNA modification in mammals and other eukaryotes, regulates DNA mismatch repair, chromosome replication, and transcription. However, its role in adult hippocampal neurogenesis remains unkown.
Yuanfei Wu, Wenhui Ma, Qingqing Li, Yang Li, Linjie Xie, Xuejian Kong, Shuwei Chen, Qian Wang, Aiguo Xuan   +8 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Design of Selective Detector for Distributed Targets Through Stochastic Characteristic of the Fictitious Signal

Sensors
We investigate the problem of detecting the distributed targets buried in the Gaussian noise whose covariance matrix is unknown when signal mismatch occurs.
Gaoqing Xiong, Hui Cao, Weijian Liu, Jialiang Zhang, Kehao Wang, Kai Yan   +5 more
doaj   +1 more source

Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability

Oncogene, 2002
Breast cancer is the most common cancer in women, but its pathogenesis is still unclear. Microsatellite instability (MSI) has been identified in breast cancer cells, suggesting an association with mismatch repair defects. To test this hypothesis, we investigated MSI, protein expression of hMSH2 and hMLH1, as well as genetic and epigenetic modifications
Hiroaki Murata, Nada H Khattar, Yuna Kang, Liya Gu, Guo-Min Li   +4 more
openaire   +3 more sources

Methyl directed DNA mismatch repair in Vibrio cholerae [PDF]

, 1994
Mismatches in DNA occur either due to replication error or during recombination between homologous but non-identical DNA sequences or due to chemical modification of bases.
Sengupta, Aditya, Aditya Sengupta, Das, Jyotirmoy, Kishor K. Bhakat, Bhakat, Kishor K., Chitra Dutta, Rupa Bandyopadhyay, Jyotirmoy Das, Bandyopadhyay, Rupa, Dutta, Chitra, Bera, Tapan K., Tapan K. Bera   +11 more
core   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source