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Kinetics of misonidazole enantiomers
Clinical Pharmacology and Therapeutics, 1984The kinetics of misonidazole enantiomers were followed in nine healthy subjects after a single oral dose of racemic misonidazole (1.0 gm/m2). Mean clearance of (+)-misonidazole was 14% greater than that for (-)-misonidazole and mean volume of distribution was slightly greater (3%) for the (+)-enantiomer.
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Radiation-Enhanced Cytotoxicity of Misonidazole
Radiation Research, 1981KORBELIK, M., PALCIC, B., AND SKARSGARD, L. D. Radiation-Enhanced Cytotoxicity of Misonidazole. Radiat. Res. 88, 343-353 (1981). The effect of ionizing radiation on the toxicity of misonidazole to hypoxic mammalian cells was examined. Cell toxicity response (log surviving fraction vs time of exposure to misonidazole in hypoxia) can be approximated by a
M, Korbelik, B, Palcic, L D, Skarsgard
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2000
Abstract Misonidazole, a 2-nitroimidazole compound, is a hypoxic cell radiosensitizer used to sensitize radioresistant tumor cells. Neurotoxicity consists of a dose-limiting, predominantly sensory peripheral neuropathy and, at high doses, encephalopathy.
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Abstract Misonidazole, a 2-nitroimidazole compound, is a hypoxic cell radiosensitizer used to sensitize radioresistant tumor cells. Neurotoxicity consists of a dose-limiting, predominantly sensory peripheral neuropathy and, at high doses, encephalopathy.
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Chemosensitization of mouse tumors by misonidazole
International Journal of Radiation Oncology*Biology*Physics, 1982The chemosensitizing action of misonidazole when used in combination with chemotherapeutic drugs has been assessed in two mouse tumors. Regrowth delay has been used as the assay, and by producing dose-response curves the effect has been classified as additive or interactive. A very small additive effect was seen with bleomycin and adriamycin.
V S, Randhawa, F A, Stewart, J, Denekamp
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Electroneurographic Investigations of Misonidazole Polyneuropathy
European Neurology, 200813 patients with malignant tumors were treated by the radiosensitizer misonidazole (Ro 07–0582), total dosage 20–29 g. The electrophysiological investigations showed (1) an early increase of distal latency, the motor nerve conduction velocity (NCV) of the peroneal nerve and the NCV of the sural nerve remaining normal or only slightly reduced, and in a ...
B, Mamoli +4 more
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Glutathione Depletion and Misonidazole Efficiency
The British Journal of Radiology, 1985Shrieve and Denekamp (1985) conclude that misonidazole (MISO) is not more efficient in GSH-depleted cells than in untreated cells. They point out that although their experimental studies on the radiosensitisation of GSH-depleted hypoxic cells by oxygen or MISO (Shrieve et al, 1984) are similar to those of others in the literature, their conclusion is ...
J M, Brown, E A, Bump
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Misonidazole and potentially lethal damage
International Journal of Radiation Oncology*Biology*Physics, 1982The existence of potentially lethal damage (PLD) is demonstrated in exponentially growing CHO cells exposed to misonidazole in hypoxia. The method of hypertonic post-treatment of cells was used in these studies. Misonidazole-induced PLD differs in many characteristics from radiation-induced PLD.
M, Korbelik +3 more
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Flash Photolysis of Misonidazole and Metronidazole
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1987Laser flash photolysis at 355 nm of misonidazole or metronidazole in aqueous solutions produced the relatively long-lived nitro radical anion as the only observable transient species. When 266 nm excitation was used, a small yield of solvated electron was observed.
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The Radiation Reduction of Misonidazole
Radiation Research, 1981[14C]Misonidazole, a 2-nitroimidazole radiation sensitizer, was reduced in dilute aqueous solution by irradiation in the absence of oxygen and in the presence of excess formate ions. In solutions buffered at pH 7.0 the misonidazole absorption spectrum is lost with increasing radiation exposure, consuming 4.0 + 0.2 reducing equivalents per molecule ...
D. W. Whillans, G. F. Whitmore
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Acta neurologica Scandinavica. Supplementum, 1984
Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
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Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
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