Results 131 to 140 of about 2,768 (167)
Some of the next articles are maybe not open access.
Electroneurographic Investigations of Misonidazole Polyneuropathy
European Neurology, 197913 patients with malignant tumors were treated by the radiosensitizer misonidazole (Ro 07-0582), total dosage 20-29 g. The electrophysiological investigations showed (1) an early increase of distal latency, the motor nerve conduction velocity (NCV) of the peroneal nerve and the NCV of the sural nerve remaining normal or only signlty reduced, and in a ...
B, Mamoli +4 more
openaire +2 more sources
Misonidazole and potentially lethal damage
International Journal of Radiation Oncology*Biology*Physics, 1982The existence of potentially lethal damage (PLD) is demonstrated in exponentially growing CHO cells exposed to misonidazole in hypoxia. The method of hypertonic post-treatment of cells was used in these studies. Misonidazole-induced PLD differs in many characteristics from radiation-induced PLD.
M, Korbelik +3 more
openaire +2 more sources
Comparison of Binding of [ 3 H]Misonidazole and [ 14 C]Misonidazole in Multicell Spheroids
Radiation Research, 1985Uptake of [2-ring-14C]misonidazole and [3H]misonidazole with tritium in the side chain has been compared in 1-mm EMT-6/UW spheroids using liquid scintillation counting and autoradiography. The uptake of both labeled sensitizers as a function of incubation time was virtually identical.
J S, Rasey +4 more
openaire +2 more sources
Glutathione conjugates of misonidazole
Biochemical and Biophysical Research Communications, 1983The hydroxylamine derivative of misonidazole reacts with glutathione under physiological conditions to form two isomeric conjugates. Based on physical and chemical properties, the two conjugates have been identified as 1-[2-amino-(4-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol and 1-[2-amino-(5-glutathion-S-yl)-1-imidazolyl]-3-methoxypropanol.
openaire +2 more sources
Kinetics of misonidazole enantiomers
Clinical Pharmacology and Therapeutics, 1984The kinetics of misonidazole enantiomers were followed in nine healthy subjects after a single oral dose of racemic misonidazole (1.0 gm/m2). Mean clearance of (+)-misonidazole was 14% greater than that for (-)-misonidazole and mean volume of distribution was slightly greater (3%) for the (+)-enantiomer.
openaire +2 more sources
Misonidazole-induced thymidine release from DNA
Biochemical Pharmacology, 1981Abstract Misonidazole reduced electrolytically at constant potential in the presence of DNA of varying base composition has been shown to release specifically a mixture of thymidine mono- and diphosphates. Release is not dependent upon helix integrity nor upon base sequences.
R J, Knox, R C, Knight, D I, Edwards
openaire +2 more sources
Enhancement of Misonidazole Cytotoxicity by Iron
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1985The toxicity of misonidazole (MISO) to hypoxic Chinese hamster ovary (CHO) cells in serum-free medium is enhanced by Fe(III)-EDTA. Enhancement of MISO cytotoxicity by a factor of 1.6 was seen with 2 microM Fe(III)-EDTA, while 200 microM Fe(III)-EDTA results in sensitization by a factor of 2.0.
A, Samuni +3 more
openaire +2 more sources
Chemosensitization of mouse tumors by misonidazole
International Journal of Radiation Oncology*Biology*Physics, 1982The chemosensitizing action of misonidazole when used in combination with chemotherapeutic drugs has been assessed in two mouse tumors. Regrowth delay has been used as the assay, and by producing dose-response curves the effect has been classified as additive or interactive. A very small additive effect was seen with bleomycin and adriamycin.
V S, Randhawa, F A, Stewart, J, Denekamp
openaire +2 more sources
Acta neurologica Scandinavica. Supplementum, 1984
Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
openaire +1 more source
Neurotoxic side effects of misonidazole with peripheral neuropathy was investigated in two series of patients. The first series consisted of eight patients with carcinoma of the pharynx, larynx or lung who, during treatment with misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs localized mainly to the lower ...
Paulson, O B +8 more
openaire +1 more source
Misonidazole: Inter-related factors affecting cytotoxicity
International Journal of Radiation Oncology*Biology*Physics, 1982A detailed investigation was undertaken of reported modifiers of the toxicity towards hypoxic cells of misonidazole. The modifiers tested were medium type, cell type, cell density, concentration of misonidazole, addition of serum, addition of sulfhydryl, addition of oxygen and pH.
C J, Koch, R L, Howell
openaire +2 more sources