Results 191 to 200 of about 4,225,561 (321)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A comparison of various imputation algorithms for missing data. [PDF]

PLoS One
Kampf J, Dykun I, Rassaf T, Mahabadi AA.
europepmc   +1 more source

Quantile regression for longitudinal data: unobserved heterogeneity and informative missingness [PDF]

, 2015
Maria Francesca Marino, Nikos Tzavidis, Marco Alfò   +2 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Regulatory Experiences with the Use of Multiple Imputation for Missing Data in a Phase 3 Confirmatory Trial. [PDF]

Ther Innov Regul Sci
Sassi-Sayadi M, Verweij P, Cornelisse P.
europepmc   +1 more source

Pattern classification with missing data using belief functions

, 2014
Z. Liu, Quan Pan, G. Mercier, Jean Dezert   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Missing Data in OHCA Registries: How Imputation Methods Affect Research Conclusions-Paper I. [PDF]

J Clin Med
Zhan SJ, Saffari SE, Ong MEH, Siddiqui FJ.   +3 more
europepmc   +1 more source

"Equation missing" All Your Data Are Belong to us"Equation missing" . European Perspectives on Privacy Issues in ‘Free’ Online Machine Translation Services

, 2016
Paweł Kamocki, Jim O’Regan, Marc Stauch   +2 more
openalex   +2 more sources

Doubly Robust-Based Generalized Estimating Equations for the Analysis of\n Longitudinal Ordinal Missing Data [PDF]

, 2015
José Luiz P. da Silva, Enrico A. Colosimo, Fábio N. Demarqui   +2 more
openalex   +1 more source