Results 71 to 80 of about 607,299 (306)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

open access: yesAdvanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang   +9 more
wiley   +1 more source

Visas, Inc: Corporate Control and Policy Incoherence in the U.S. Temporary Foreign Labor System [PDF]

open access: yes, 2012
This report provides the first comprehensive analysis of the many visas that employers use and misuse to bring foreign workers into the U.S. in every field, from low-wage jobs in agriculture and domestic work, to specialty occupations in health care ...
Ashwini Sukthankar
core  

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

open access: yesAdvanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang   +13 more
wiley   +1 more source

New approaches to parental substance misuse [PDF]

open access: yes, 2011
This article is made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 HarwinParental substance misuse is a major social problem. No-one knows exactly how many children are growing up in families where one or both parents have a
Harwin, J
core  

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

open access: yesAdvanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar   +7 more
wiley   +1 more source

Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse

open access: yesMolecules, 2020
Several over-the-counter (OTC) drugs are known to be misused. Among them are opioids such as codeine, dihydrocodeine, and loperamide. This work elucidates their pharmacology, interactions, safety profiles, and how pharmacology is being manipulated to ...
Łukasz Sobczak, Krzysztof Goryński
doaj   +1 more source

The prevalence of cocaine-associated chest pain in a London hospital [PDF]

open access: yes, 2004
Objectives: To determine the prevalence of cocaine misuse in patients presenting to an Accident and Emergency department with chest pain.
Bandeeri, N.   +3 more
core  

Reproducible Research: Best Practices and Potential Misuse

open access: yes, 2019
The scientific world is becoming more open to the public and fellow researchers. Open access publishing is becoming accepted, even if some publishers are resisting.
Björnson, Emil
core   +1 more source

Masculine Misuse [PDF]

open access: yes, 2016
A review of:Raymond MalewitzThe Practice of Misuse: Rugged Consumerism in Contemporary American CultureStanford University Press, Stanford, 2014ISBN: 9780804791960 US$55 ...
Gleeson-White, Sarah
core   +3 more sources

Biology’s Misuse Potential [PDF]

open access: yesConnections: The Quarterly Journal, 2016
The Misuse of BiologyThe international community has laid down clear red lines about the misuse of biology. The two biological cornerstones of the rules of war are the Biological Weapons Convention (BWC) and the Geneva Protocol. Together, they prohibit the development, production, stockpiling and use of biological weapons.
openaire   +2 more sources

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