Results 251 to 260 of about 4,447,971 (326)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

[AI-enabled clinical decision support systems: challenges and opportunities]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Tschochohei M, Adams LC, Bressem KK, Lammert J.   +3 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A hybrid metaheuristic framework for epileptic seizure detection in healthcare decision support systems. [PDF]

Acta Epileptol
Dokare I, Gupta S.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ultra-broadband and passive stabilization of ultrafast light sources by quantum light injection. [PDF]

Nanophotonics
Rivera N, Uddin SZ, Sloan J, Soljačić M.   +3 more
europepmc   +1 more source

Hybrid machine learning models for enhanced arrhythmia detection from ECG signals using autoencoder and convolution features. [PDF]

PLoS One
Biswas S, Sahoo PK, Kumar B, Rath A, Jain P, Panda G, Liu H, Wang X.   +7 more
europepmc   +1 more source

Delays in Pediatric Studies Required Under the US Pediatric Research Equity Act.

JAMA Netw Open
McGonigle R, Bourgeois FT.
europepmc   +1 more source

An epilepsy prediction and management system based on federated learning combined with hybrid harmony search and mutual information (HAS-MI)-based feature selection approach. [PDF]

Sci Rep
Khan MAR, Heba KM, Abbass AH, Shaikh MA, Tejani GG, Sharma SK, Ma'aitah MKS.   +6 more
europepmc   +1 more source

Hybrid deep learning-enabled framework for enhancing security, data integrity, and operational performance in Healthcare Internet of Things (H-IoT) environments. [PDF]

Sci Rep
Naik N, Surendranath N, Raju SAB, Madduri C, Dasari N, Shukla VK, Patil V.   +6 more
europepmc   +1 more source