Results 71 to 80 of about 16,695 (262)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Praktiken der Zugehörigkeit im Flüchtlingscamp. Die urdusprachige Minderheit in Bangladesch – der lange Schatten der indischen Teilung

Zeithistorische Forschungen, 2018
Das Ende der britischen Kolonialherrschaft in Indien 1947 zerteilte das Land nicht nur, sondern verursachte auch (jahrzehntelange) Migrationsbewegungen.
Anna Greshake
doaj   +1 more source

Analisis Model Reference Adaptive Control (MRAC) dengan MIT Rule pada Suhu Mesin Sealer

Jurnal Elektronika dan Otomasi Industri
Mesin sealer merupakan alat yang penting dalam industri untuk mengirimkan plastik dan mengemas bahan, dengan aplikasi di industri makanan, minuman, farmasi, dan manufaktur. Proses pendaftaran ini penting untuk menjaga kesegaran produk, meningkatkan keamanan, dan estetika kemasan. Tantangan yang dihadapi dalam penggunaan mesin sealer meliputi pengaturan
Sri Aji Eka Mahendra Sri Aji Eka Mahendra, null Basitha Febrinda Hidayatulail, null Subairi   +2 more
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Fractional Model Reference Adaptive PIλDμ Control

Journal of New Results in Science, 2016
This study explains the auto-adjustable fractional order the proportional–integral–derivative (PID) controller design methodology by using the technique of fractional model reference adaptive control (fractional MRAC).
Hüseyin Arpacı, Ömerül Faruk Özgüven, Mehmet Serhat Can   +2 more
doaj  

Effect Of Adaptation Gain On System Performance For Model Reference Adaptive Control Scheme Using Mit Rule

, 2010
{"references": ["Karl J. Astrom, Bjorn Wittenmark, \"Adaptive control\" , 2nd ed.\nPearson Education Asia, 2001, pp185-225.", "Rey-Chue Hwang, Huang-Chu Huang, Wei-Shen Chi, \"A New\nFuzzy PID-Like Controller\", IEEE international conference on\nsystems, man, cybernetics, vol. 5, 2000.", "K. S.
Swarnkar, Pankaj, Jain, Shailendra, R.K Nema   +2 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source