Results 61 to 70 of about 405 (131)

Treating pyruvate kinase deficiency with Mitapivat: a short communication

Annals of Medicine & Surgery, 2023
Muhammad Omar Larik, Moeez Ibrahim Shiraz, Muhammad Ashhal Iftekhar, Seemin Afshan Shiraz, Maira Shiraz   +4 more
openaire   +2 more sources

P1546: ACTIVATE-KIDST: MITAPIVAT IN CHILDREN WITH PYRUVATE KINASE DEFICIENCY WHO ARE REGULARLY TRANSFUSED

HemaSphere, 2022
R. F. Grace, P. D. Tyler, M. Little, P. A. Kosinski, V. Beynon   +4 more
doaj   +1 more source

Bone mineral density in adult patients with pyruvate kinase deficiency on long-term mitapivat treatment

Haematologica, 2023
Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthøj, Oliver Andres, Wilma Barcellini, Frédéric Galacteros, Kevin H. M. Kuo, D. Mark Layton, Marta Morado, Vip Viprakasit, Feng Tai, Rolandas Urbstonaitis, Jaime Morales, Bryan McGee, Eduard J. van Beers   +14 more
doaj   +1 more source

Three-year safety, efficacy, and renal outcomes of mitapivat treatment in sickle cell disease: results from the phase 2 open-label study

Haematologica
Not available.
Geoffrey Z.L. Kuppens, Maria Armila D. Ruiz, Myrthe J. van Dijk, Minke A.E. Rab, Cleo Derichs, Joline Saes, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Santosh L. Saraf, Eduard J. van Beers   +12 more
doaj   +1 more source

P1547: ACTIVATE-KIDS: MITAPIVAT IN CHILDREN WITH PYRUVATE KINASE DEFICIENCY WHO ARE NOT REGULARLY TRANSFUSED

HemaSphere, 2022
R. F. Grace, P. D. Tyler, M. Little, P. A. Kosinski, V. Beynon   +4 more
doaj   +1 more source

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice

Haematologica, 2023
Alessandro Mattè, Penelope A. Kosinski, Enrica Federti, Lenny Dang, Antonio Recchiuti, Roberta Russo, Angela Siciliano, Veronica Riccardi, Anne Janin, Matteo Mucci, Christophe Leboeuf, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi   +13 more
doaj   +1 more source

Influence of the pyruvate kinase activator mitapivat (AG-348) on RBC ATP content and export and RBC adhesivity in blood from healthy subjects and sickle cell disease patients

Frontiers in Hematology
BackgroundSickle cell disease (SCD) represents a significant global health burden and is characterized by hemolytic anemia, vaso-occlusive crises, end-organ damage, and early mortality.
Apoorva Jagadish, Youwei Chen, Hongmei Zhu, Hongmei Zhu, Weijia Mai, Shein-Chung Chow, Zhong Li, Grace M. Lee, Marilyn J. Telen, Tim J. McMahon, Tim J. McMahon   +10 more
doaj   +1 more source

PB2247: PHARMACOKINETIC MODELING AND SIMULATION TO SUPPORT MITAPIVAT DOSE SELECTION USED IN PEDIATRIC PHASE III STUDIES

HemaSphere, 2022
O. Yin, K. Baron, J. Mondick, M. Little, P. D. Tyler, V. Beynon   +5 more
doaj   +1 more source

P1565: MITAPIVAT IMPROVES INEFFECTIVE ERYTHROPOIESIS AND REDUCES IRON OVERLOAD IN PATIENTS WITH PYRUVATE KINASE DEFICIENCY

HemaSphere, 2022
E. J. van Beers, H. Al-Samkari, R. F. Grace, W. Barcellini, A. Glenthøj, M. P. Judge, P. A. Kosinski, R. Xu, V. Beynon, B. McGee, J. B. Porter, K. H. M. Kuo   +11 more
doaj   +1 more source

P107: A PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MITAPIVAT IN PATIENTS WITH SICKLE CELL DISEASE

HemaSphere, 2022
J Howard, K Kuo, A Oluyadi, H Shao, S Morris, A Zaidi, E Van Beers, S Thein   +7 more
doaj   +1 more source