Results 81 to 90 of about 405 (131)

The Efficacy of Mitapivat in Case of Transfusion Dependence Linked to Beta Thalassemia Trait Associated with Pyruvate Kinase Deficiency. [PDF]

J Cell Mol Med
Fatigati C, Costantini S, Spasiano A, Ziello B, Gambale A, Ricchi P.   +5 more
europepmc   +1 more source

Pyruvate kinase activators: targeting red cell metabolism in sickle cell disease. [PDF]

Hematology Am Soc Hematol Educ Program, 2023
Xu JZ, Vercellotti GM.
europepmc   +1 more source

Mitapivat Pyruvate Kinase Activation: Metabolic Reprogramming Beyond Current Indications

ClinicalTrials.gov identifies NCT05675436 investigating mitapivat mechanistic effects in sickle cell disease, currently active but not recruiting. Open Targets shows PKLR (pyruvate kinase) with 0.39 disease association. UniProt describes PKLR as catalyzing phosphoenolpyruvate to pyruvate conversion with ATP synthesis.
openaire   +1 more source

Response to Mitapivat: A Quinolone Sulfonamide to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency. [PDF]

Am J Ther
Boscoe A, McCracken R, Marathe P, Osman K.   +3 more
europepmc   +1 more source

Reporting on Therapeutic Advancements Requires Accurate Language. [PDF]

Am J Ther
McCracken R, Boscoe A, Marathe P, Osman K.   +3 more
europepmc   +1 more source

Mitapivat versus Placebo for Pyruvate Kinase Deficiency. Reply

, 2022
Al-Samkari,Hanny, Beynon,Vanessa, van Beers, Eduard J., Poli Van Creveldkliniek Medisch, Child Health   +4 more
openaire   +1 more source

Flawed Value Assessment of Mitapivat to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency. [PDF]

Am J Ther
Boscoe A.
europepmc   +1 more source

Beyond adenosine triphosphate: unveiling the pleiotropic effects of pyruvate kinase activation in sickle cell anemia. [PDF]

Haematologica
Glenthøj A.
europepmc   +1 more source

Mitapivat improves ineffective erythropoiesis and iron overload in adult patients with pyruvate kinase deficiency. [PDF]

Blood Adv
van Beers EJ, Al-Samkari H, Grace RF, Barcellini W, Glenthøj A, DiBacco M, Wind-Rotolo M, Xu R, Beynon V, Patel P, Porter JB, Kuo KHM.   +11 more
europepmc   +1 more source

From old to new: Repurposed drugs in the battle towards curing sickle cell disease. [PDF]

Br J Haematol
El Hoss S, Bazoum H.
europepmc   +1 more source