Results 61 to 70 of about 4,851,512 (253)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Flood Mitigation in Ethekwini Metropolitan Area – Empirical Evidence using Artificial Neural Network [PDF]
E-Journal of Humanities, Arts and Social SciencesKnowledge of flood patterns is very crucial for developing mitigation strategies and flood risk management. Historical data for floods in the SADC region from 2000 to 2016 indicates 198 flood occurrences leading to total deaths of 3,974, injuries of 2 ...
Caroline C. Olanrewaju +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Other title: Hazard Mitigation Plan
, 2013 [Revised] October 14, 2013 Includes bibliographical and internet references.The purpose of the Kansas Hazard Mitigation Plan is to guide hazard mitigation to better protect the people and property of the State.
Kansas Hazard Mitigation Team.
core +1 more source
Extreme heat in Koudougou, Burkina Faso: Analysing trends, community perceptions and migration measures [PDF]
Glasnik Srpskog Geografskog DruštvaClimate change is having a profound impact on urban population in the Sahel region, particularly in Burkina Faso, affecting various aspects of daily life. Koudougou, the third largest city in the country, is not exempted. The aim of this article
Yo Boureima +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Chapter 16: Mitigation Strategies for Microfiber Pollution
In this chapter, an outline of the available strategies for mitigating microfiber contamination is presented. As most of the microfibers enter the environment from the washing of synthetic clothing, most mitigation strategies have mainly focused on ...
Erika Iveth Cedillo Gonzalez
core +1 more source
Forest Fuels and Hazard Mitigation Work Group Final Report
As part of the 2004 Oregon Fire Program Review, the Oregon Department of Forestry (ODF) formed the Forest Fuels and Hazard Mitigation (FFHM) Committee to assess hazardous fuel loading issues, and recommend ways to reduce risk, and improve and strengthen ...
Forest Fuels and Hazard Mitigation Committee
core +6 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source