Results 81 to 90 of about 4,851,512 (253)

Adaptation, Mitigation and “Green” R&D to Combat Global Climate Change. Insights From an Empirical Integrated Assessment Exercise [PDF]

This work develops a framework for the analysis at the macro-level of the relationship between adaptation and mitigation policies. The FEEM-RICE growth model with stock pollution, endogenous R&D investment and emission abatement is enriched with a ...
Francesco Bosello
core  

Integrating climate change mitigation and adaptation options into farms in the Southwest of Western Australia [PDF]

, 2011
This research reviews existing climate change literature and quantifies the climate change mitigation and adaptation potential of specific agricultural diversification activities at an individual farm level.
McHenry, Mark
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A global approach to near-Earth object impact threat mitigation [PDF]

, 2011
There is currently no concerted international plan addressing the impact threat and how to organize, prepare and implement mitigation measures. We report on a new international project to address impact hazard mitigation issues, being the subject of a ...
Payson, D., Hestroffer, Daniel, Cano, J. L., Schaefer, F., Barucci, Maria Antonella, Lork, W., Hestroffer, D., Cano, J.L., Harris, A.W., Morrison, D., Fitzsimmons, Alan, Schäfer, F., Fitzsimmons, A., Harris, Alan W., Michel, Patrick, Morrison, David, Lappas, V., Barucci, M.A., Fulchignoni, M., Green, S. F., Green, S.F., Michel, P., Fulchignoni, Marcello   +22 more
core  

The Implications of Intermediate Stop Operations on Aviation Emissions and Climate

Meteorologische Zeitschrift, 2017
Among the various transport modes aviation's impact on climate change deserves special attention. Due to typical flight altitudes in the upper troposphere and above, the effect of aircraft engine emissions like e.g.
Florian Linke, Volker Grewe, Volker Gollnick   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Investigating the Effect of Blue–Green Infrastructure on Thermal Condition—Case Study: Elazığ, Turkey

Land
This study examines the thermal impacts of green and blue infrastructure in Hilalkent Neighborhood, Elazığ City, in Turkey, using ENVI-met 5.6.1 software.
Sevgi Yilmaz, Yaşar Menteş, Elmira Jamei   +2 more
doaj   +1 more source