Results 91 to 100 of about 616,349 (353)

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Idiopathic Normal-Pressure Hydrocephalus Revealed by Systemic Infection: Clinical Observations of Two Cases

Neurology International
Background/Objectives: Idiopathic normal-pressure hydrocephalus (iNPH) is a potentially reversible neurological disorder characterized by gait disturbance, cognitive impairment, and urinary incontinence.
Shinya Watanabe, Yasushi Shibata, Kosuke Baba, Yuhei Kuriyama, Eiichi Ishikawa   +4 more
doaj   +1 more source

Triple Experiment Spectrum of the Sunyaev-Zeldovich Effect in the Coma Cluster: H_0

, 2003
The Sunyaev-Zeldovich (SZ) effect was previously measured in the Coma cluster by the Owens Valley Radio Observatory and Millimeter and IR Testa Grigia Observatory experiments and recently also with the Wilkinson Microwave Anisotropy Probe satellite.
A. Melchiorri, A. Orlando, Birkinshaw M., Cavaliere A., E. Palladino, E. S. Battistelli, F. Melchiorri, G. Luzzi, G. Savini, L. Lamagna, M. De Petris, M. Shimon, M. Signore, Masi S., R. Maoli, S. Colafrancesco, Sunyaev R. A., Y. Rephaeli   +17 more
core   +1 more source

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis [PDF]

, 2004
A dynamic balance of organelle fusion and fission regulates mitochondrial morphology. During apoptosis this balance is altered, leading to an extensive fragmentation of the mitochondria.
Arnoult, Damien, Chan, David C., Chen, Hsuichen, Karbowski, Mariusz, Smith, Carolyn L., Youle, Richard J.   +5 more
core   +2 more sources

Doença na recepção do mito de Filoctetes no Regime Militar brasileiro: “Ramom, o Filoteto Americano” de Carlos Henrique Escobar

, 2021
Mateus Dagios
openalex   +2 more sources

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer has a poor prognosis. Xanthatin directly targets and degrades CISD1, triggering ferroptosis through iron dysregulation. The concurrently activated mitophagy synergistically amplifies ferroptotic cell death. Xanthatin also demonstrates potent in vivo anti‐tumor efficacy with minimal toxicity, highlighting its therapeutic ...
Qinwen Liu, Haojie Chen, Xiang Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lu, Daogang Guan   +9 more
wiley   +1 more source

Specific Heat Study of an S=1/2 Alternating Heisenberg Chain System F_5PNN Under Magnetic Field [PDF]

, 2004
We have measured the specific heat of an S=1/2 antiferromagnetic alternating Heisenberg chain pentafulorophenyl nitronyl nitroxide under magnetic fields up to H>H_C2. This compound has the field-induced magnetic ordered (FIMO) phase between H_C1 and H_C2.
K. Inoue, K. Takeda, M. Mito, M. Tachiki, M. Takahashi, N. Tateiwa, T. Kawae, Y. Hosokoshi, Y. Yoshida   +8 more
core   +4 more sources

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Don Juan Tenório: um herói reabilitado? [PDF]

, 2012
Concebido por Tirso de Molina em 1630 como afirmação do individualismo da era moderna, o mito de Don Juan gozou da maior divulgação que um mito poderá porventura ter, passou por várias fases de acordo com a evolução ideológica das sociedades por que ...
Sequeira, Rosa Maria
core  

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source