Results 271 to 280 of about 616,349 (353)

Expanding research and care for Leigh syndrome: efforts of a patient-led advocacy organization. [PDF]

Res Involv Engagem
Zilber S, Burnworth M, Afolabi T, Brestoff JR, Minczuk M, Luis AR, Ling Q, Prigione A, Tolle I, Elsharkawi I, Perlstein E, Boyce D, Johnson S, Woleben K.   +13 more
europepmc   +1 more source

High‐Purity Functional Corneal Endothelial Cells From Human Induced Pluripotent Stem Cells via a Novel Wash‐Out Method

MedComm, Volume 7, Issue 4, April 2026.
iPSC‐derived corneal endothelial cells purified via a novel wash‐out method show high functional fidelity, resemble primary CECs, and restore corneal clarity in vivo, offering a scalable alternative to donor transplantation. ABSTRACT Corneal endothelial failure can cause blindness, with transplantation as the only treatment.
Eun‐Ah Ye, Changmin Kim, Minah Jeon, Yeji Yoon, Jiyoon Park, Ryun Hee Lee, Carson Yu, Ho Seok Chung, Jae Yong Kim, David Myung, Hun Lee   +10 more
wiley   +1 more source

Immune regulators PALS-25 and PALS-22 localize to mitochondria and regulate mitochondrial fragmentation in <i>C. elegans</i>. [PDF]

iScience
Gang SS, Strul MW, Richmond-Buccola D, Troemel ER.   +3 more
europepmc   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Mito-Genipin, a Novel Mitochondria-Targeted Genipin Derivative Modulates Oxidative Stress and Inflammation in Macrophages. [PDF]

Antioxidants (Basel)
Angi B, Di Molfetta D, Pendin D, Antoniazzi G, Flora CA, De Leonardis F, Buono M, Fiermonte G, Szabo I, Mattarei A, Varanita T.   +10 more
europepmc   +1 more source

FGF21‐Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

Aging Cell, Volume 25, Issue 4, April 2026.
FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu, Rui Ran, Qi‐qi Xie, Cong Zhang, Ya‐jun Chen, Peng Cheng, Ke‐Ping Wang, Hai‐hong Zhang   +7 more
wiley   +1 more source

Milk fat globule-EGF factor 8/ATP-binding cassette subfamily E member 1 axis maintains mitophagy flux homeostasis to suppress ferroptosis in acute pancreatitis. [PDF]

Clin Transl Med
Ren Y, Lu Y, Cui Q, Shang H, Fan M, Sun Y, Shi X, Wu R, Lu H.   +8 more
europepmc   +1 more source

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source