Results 281 to 290 of about 616,349 (353)
FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS-FTD-associated CHCHD10<sup>S59L</sup> in <i>Drosophila</i> and human cells. [PDF]
Maitra S +4 more
europepmc +1 more source
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu +6 more
wiley +1 more source
Optimizing the Seahorse XF Mito Stress Test Workflow and Troubleshooting Notes: A Stepwise Protocol for HUVECs. [PDF]
Wang J +5 more
europepmc +1 more source
Fruit respiration: putting alternative pathways into perspective
Summary Over the past century, research has significantly advanced our understanding of fruit respiration, from (eco)physiological processes to molecular mechanisms. This review focuses on the functional relevance and regulatory roles of mitochondrial alternative respiratory pathways (ARPs) during fruit growth and ripening.
Ariadna Iglesias‐Sanchez +4 more
wiley +1 more source
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang +6 more
wiley +1 more source
Ultrasound-guided guidewire maneuver to resolve peritoneal drainage catheter obstruction in an infant: A case report. [PDF]
Homma R +4 more
europepmc +1 more source
The mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Zhen Yin +12 more
wiley +1 more source
Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1. [PDF]
Falk JE +7 more
europepmc +1 more source

