Results 281 to 290 of about 616,349 (353)

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu   +6 more
wiley   +1 more source

Fruit respiration: putting alternative pathways into perspective

open access: yesNew Phytologist, Volume 250, Issue 1, Page 54-73, April 2026.
Summary Over the past century, research has significantly advanced our understanding of fruit respiration, from (eco)physiological processes to molecular mechanisms. This review focuses on the functional relevance and regulatory roles of mitochondrial alternative respiratory pathways (ARPs) during fruit growth and ripening.
Ariadna Iglesias‐Sanchez   +4 more
wiley   +1 more source

Multi‐Omics Combined With Mitochondrial Feeding Assays Reveal a Novel Energy Metabolism Strategy for Floral Thermogenesis in Magnolia Driven by Synergistic Supply of Multiple Substrates

open access: yesPlant Biotechnology Journal, Volume 24, Issue 4, Page 2169-2183, April 2026.
ABSTRACT The high demand for energy during floral thermogenesis drives the synergistic operation of multiple energy substrates for the rapid temperature rise and successful reproduction of flowers. However, how thermogenic plants precisely regulate substrate supply and metabolic pathways within a short time to support large‐scale energy and heat ...
Siqin Wang   +6 more
wiley   +1 more source

CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1‐Dependent RAS/MAPK Activation

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Zhen Yin   +12 more
wiley   +1 more source

Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1. [PDF]

open access: yesJ Cell Biol
Falk JE   +7 more
europepmc   +1 more source

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