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Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

open access: yesInternational Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis. [PDF]

open access: yesProc Natl Acad Sci U S A
Ndoj K   +10 more
europepmc   +1 more source

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