Results 161 to 170 of about 618,328 (350)
British Journal of Haematology, EarlyView.Summary Mixed phenotype acute leukaemia (MPAL) is a rare subtype of acute leukaemia possessing significant therapeutic challenges, as no standardized, evidence‐based treatment regimen has been defined. In this nationwide study, we aimed to assess the effect of an acute lymphoid leukaemia (ALL)‐like regimen; an acute myeloid leukaemia (AML)‐like regimen;
Lisa‐Maj Christensen +11 more
wiley +1 more source
Entre Brasil e Portugal: Os Sertões e o mito sebástico
, 1996 Paulo Fernando Motta Oliveira
openalex +1 more source
Pague Menos, Leve Mais: o mito da qualidade de vida no balcão da maior rede de farmácias do Brasil [PDF]
, 2013 André Luiz Maranhão de Souza Leão +2 more
openalex +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source
Cancer Science, EarlyView.Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...
Wan‐Hang Zhou +2 more
wiley +1 more source
Del mito creacionista al mito futurista
Calle 14: Revista de Investigación en el Campo del Arte, 2011 La primera foto tomada a la Tierra desde el espacio, en 1946, es uno de los signos de la reprogramación mitológica que está afectando la percepción actual de las ciencias y las artes. Esta reprogramación opone a Dios como artífice y al artista como dios creador: un superhumano tecnólogo y un artista administrador de la Tierra.
openaire +1 more source
Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling
Cell Proliferation, EarlyView.We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo +4 more
wiley +1 more source
The FEBS Journal, EarlyView.Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan +8 more
wiley +1 more source