Results 191 to 200 of about 62,676 (260)

Energy stress activates AMPK to arrest mitochondria via phosphorylation of TRAK1. [PDF]

J Cell Biol
Falk JE, Henke T, Gowrisankaran S, Wanderoy S, Basu H, Greally S, Steen J, Schwarz TL.   +7 more
europepmc   +1 more source

High‐Purity Functional Corneal Endothelial Cells From Human Induced Pluripotent Stem Cells via a Novel Wash‐Out Method

MedComm, Volume 7, Issue 4, April 2026.
iPSC‐derived corneal endothelial cells purified via a novel wash‐out method show high functional fidelity, resemble primary CECs, and restore corneal clarity in vivo, offering a scalable alternative to donor transplantation. ABSTRACT Corneal endothelial failure can cause blindness, with transplantation as the only treatment.
Eun‐Ah Ye, Changmin Kim, Minah Jeon, Yeji Yoon, Jiyoon Park, Ryun Hee Lee, Carson Yu, Ho Seok Chung, Jae Yong Kim, David Myung, Hun Lee   +10 more
wiley   +1 more source

Ultrasound-guided guidewire maneuver to resolve peritoneal drainage catheter obstruction in an infant: A case report. [PDF]

Radiol Case Rep
Homma R, Toshihiko W, Futami T, Yamaoka B, Motoyama K.   +4 more
europepmc   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Baicalin attenuates cisplatin-induced cochlear hair cell damage by modulating the ROS-p38 MAPK signaling pathway. [PDF]

Front Cell Dev Biol
Zhang Q, Wang Y, Zhang C, Li S, Yin Q, Zhou C, Dong C, Bu C.   +7 more
europepmc   +1 more source

FGF21‐Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

Aging Cell, Volume 25, Issue 4, April 2026.
FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu, Rui Ran, Qi‐qi Xie, Cong Zhang, Ya‐jun Chen, Peng Cheng, Ke‐Ping Wang, Hai‐hong Zhang   +7 more
wiley   +1 more source

A molecular scaffold for concurrent targeting of plasma and mitochondrial membranes. [PDF]

Chem Sci
Lai Y, Yang Y, Zhao Y, James TD, Lin W.
europepmc   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis. [PDF]

Proc Natl Acad Sci U S A
Ndoj K, Tantucci M, Sanza P, Zubak K, Marodin G, Kingma J, Snijder F, Veenendaal T, Kober DL, Zelcer N, Klumperman J.   +10 more
europepmc   +1 more source