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Clinical Implications of HBV PreS/S Mutations and the Effects of PreS2 Deletion on Mitochondria, Liver Fibrosis, and Cancer Development

Hepatology, 2021
PreS mutants of HBV have been reported to be associated with HCC. We conducted a longitudinal study of the role of HBV preS mutations in the development of HCC, particularly in patients with chronic hepatitis B (CHB) having low HBV DNA or alanine ...
Yuh‐Jin Liang   +11 more
semanticscholar   +1 more source

Key Hepatoprotective Roles of Mitochondria in Liver Regeneration.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2023
Treatment of advanced liver disease using surgical modalities is possible due to the liver's innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating its crucial ...
Gene G Lamanilao   +9 more
semanticscholar   +1 more source

Mitochondria-Targeted Ratiometric Chemdosimeter to Detect Hypochlorite Acid for Monitoring the Drug-Damaged Liver and Kidney.

Analytical Chemistry, 2022
Liver and kidney injury caused by drug toxicity is a serious threat to human health. Acetaminophenol (APAP), as a common antipyretic and analgesic drug, inevitably causes injury.
Lina Shangguan   +4 more
semanticscholar   +1 more source

Human liver mitochondria

Clinica Chimica Acta, 1972
Abstract Contamination with hemoglobin in human liver mitochondria prepared by the procedure commonly applied to rat liver is unavoidable and a major obstacle to the measurement of cytochromes by (reduced minus oxidized) difference spectra. The washing of sliced liver tissues with Lock's solution minimized the contamination with hemoglobin.
Kazue Ozawa   +7 more
openaire   +2 more sources

Mitochondria in Chronic Liver Disease

Current Drug Targets, 2011
Mitochondria are the main energy source in hepatocytes and play a major role in extensive oxidative metabolism and normal function of the liver. This key role also assigns mitochondria a gateway function in the center of signaling pathways that mediate hepatocyte injury, because impaired mitochondrial functions affect cell survival and contribute to ...
GRATTAGLIANO I   +6 more
openaire   +3 more sources

Turnover of rat-liver mitochondria

Biochimica et Biophysica Acta, 1961
Abstract The turnover rate of four components of rat-liver mitochondria (insoluble and soluble protein, lipid and cytochrome c ) labeled with [ 35 S]methionine and [ 14 C]acetate was the same within experimental error. The data suggest that mitochondria are broken down as a unit with a half-life of 10.3 days.
M J, FLETCHER, D R, SANADI
openaire   +2 more sources

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