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Fine-tuning mitochondria to the nuclear genome
Nature Reviews Genetics, 2019A new study in Science identifies strong selective pressure on mitochondrial DNA during transmission through the female germ line, as well as an interplay with the nuclear genome that shapes mitochondrial genetic variation.
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Genomics of aging: Reactive oxidation and inefficient mitochondria
Journal of the American Association of Nurse Practitioners, 2023ABSTRACT Many things are associated with decreased health and lifespan, including cancer, diabetes, atherosclerosis, high blood pressure, and chronic inflammatory conditions. Clinicians may not be familiar with the role that mitochondrial mutations and associated mitochondrial dysfunction play in a shortened lifespan.
Kenneth Wysocki, Beth Heuer
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Bacterial genome chimaerism and the origin of mitochondria
Canadian Journal of Microbiology, 2011Many studies have sought to determine the origin and evolution of mitochondria. Although the Alphaproteobacteria are thought to be the closest relatives of the mitochondrial progenitor, there is dispute as to what its particular sister group is.
Ankur, Abhishek +3 more
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Why mitochondria need a genome revisited
FEBS Letters, 2016In this paper, we experimentally address the debate about why functional transfer of mitochondrial genes to the nucleus has been halted in some organismal groups and why cytosolic expression of mitochondrial proteins has proven remarkably difficult. By expressing all 13 human mitochondrial‐encoded genes with strong mitochondrial‐targeting sequences in ...
Björkholm P +3 more
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Functional Divergence of Mitochondria and Coevolution of Genomes: Cool Mitochondria in Hot Lizards
Physiological and Biochemical Zoology, 2018Mitochondria play a key role in the ecology and evolution of species through their influence on aerobic metabolism. Mitochondrial DNA (mtDNA) and nuclear genomes must interact for optimal functioning of oxidative phosphorylation to produce ATP, and breakdown of coadaptation components from each may have important evolutionary consequences for ...
Gregory J, Haenel +1 more
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Analysis of the genome structure of plant mitochondria
1986Publisher Summary This chapter discusses the problems and techniques necessary for the efficient analysis of mitochondrial chromosomal DNA structure. The mitochondrial genome of higher plants is larger and more complex than the mitochondrial genomes of other groups of organisms.
DAVID M. LONSDALE +2 more
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Gene duplication and transfer events in plant mitochondria genome
Biochemical and Biophysical Research Communications, 2008Gene or genome duplication events increase the amount of genetic material available to increase the genomic, and thereby phenotypic, complexity of organisms during evolution. Gene duplication and transfer events have been important to molecular evolution in all three domains of life, and may be the first step in the emergence of new gene functions ...
Ai-Sheng Xiong, Ri-He Peng
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Human Genome & Origin of Mitochondria
European Journal of Biology and Medical Science Research, 2022It had been believed that when individual eukaryotic cells engulfed aerobic and photosynthetic bacteria, the bacteria became endosymbionts with the phagocyte and evolved into mitochondria and chloroplasts respectively. The key objective of this study is to prove that the Endosymbiotic Theqory about the origins of mitochondria and chloroplasts is a ...
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Genomics of Chloroplasts and Mitochondria
2012Preface.- 1. Origins of Mitochondria and Plastids M.W. Gray, J.M. Archibald.- 2. Secondary and tertiary endosymbiosis and kleptoplasty J. Gross et al.- 3. Plastid Genomes of Algae B.F. Lang, A.M. Nedelcu.- 4. Plastomes of bryophytes, lycophytes and ferns P.G. Wolf, K.G. Karol.- 5. Plastid Genomes of Seed Plants R.K. Jansen, T.A.
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Mitochondria Genome Mutations and Cardiovascular Diseases
Translational Bioinformatics, 2018The cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality across the world. CVDs have multifactorial etiologies including environmental, lifestyle, and genetic factors. Mitochondria (mt) are indispensable organelles harboring a 16,569 base-pair, circular DNA genome that encodes 13 proteins involved in electron ...
Hui Shi +3 more
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