Results 231 to 240 of about 543,462 (281)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Taurine supplementation improves physical activity level in a hemodialysis patient with mitochondrial disease: a case report. [PDF]

CEN Case Rep
Yoshida R, Mitsuno R, Nakayama T, Azegami T, Hashiguchi A, Torimitsu T, Yoshimoto N, Hisikawa A, Hagiwara A, Nakamura T, Meguro S, Katsumata M, Endo J, Matsunaga T, Yoshino J, Kanda T, Morimoto K, Monkawa T, Yoshida T, Nakahara J, Yamaguchi S, Hayashi K.   +21 more
europepmc   +1 more source

Microenvironment Modulation‐Based Nanomaterial‐Loaded Hydrogel Dressings for Diabetic Foot Ulcers: Research Progress and Future Perspectives

Advanced Materials Interfaces, EarlyView.
xx xx. ABSTRACT Diabetic foot ulcer (DFU) is a chronic complication of diabetes, primarily caused by hyperglycemia, peripheral vascular disease, and neuropathy. Characterized by persistent hyperglycemia, impaired perfusion, inflammation, and infection, DFUs pose significant challenges to healing and are associated with high morbidity and amputation ...
Tang Yuqing, Chen Hong, Fan Weijing, Huang Renyan, You Yang, Liu Guobin   +5 more
wiley   +1 more source

Severe clinical manifestation of mitochondrial disease due to the m.3243A>T variant: a case report of early-onset, multi-organ involvement and premature death. [PDF]

J Rare Dis (Berlin)
Gillespie H, Ng YS, Wood KM, Hopton S, Alston CL, Blakely EL, Thompson N, Taylor RW, Browning AC, McFarland R, Sayer JA.   +10 more
europepmc   +1 more source

Effects of mitochondrial fusion and fission regulation on mouse hippocampal primary cultures: relevance to Alzheimer's disease

Alina Vadimovna Chaplygina, Daria Zhdanova   +1 more
openalex   +2 more sources

Organic Light‐Emitting Diode in Phototherapy Applications

Advanced Photonics Research, EarlyView.
This article systematically reviews the development of organic light‐emitting diodes (OLEDs) in phototherapy, constructs a technical framework, and establishes a multidimensional knowledge graph encompassing indications, wavelengths, and light intensity.
Yingguang Zhu, Yonglan Hu, Yingjie Cui, Lixue Guo, Guohui Zhang, Haixia Qiu, Defu Chen, Changyong Pan, Huijuan Yin, Suling Zhao   +9 more
wiley   +1 more source

Balancing Anesthesia in a Child With Mitochondrial Disease: A Case Report. [PDF]

Cureus
Manickam A, Fathima K, Bagri VA, Ganesh Prabu AVP, R VP.   +4 more
europepmc   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Mapping mitochondrial morphology and function: COX-SBFSEM reveals patterns in mitochondrial disease. [PDF]

Commun Biol
Faitg J, Davey T, Laws R, Lawless C, Tuppen H, Fitton E, Turnbull D, Vincent AE.   +7 more
europepmc   +1 more source

4-Hydroxynonenal from Mitochondrial and Dietary Source Causes Lysosomal Cell Death for Lifestyle-related Diseases

Tetsumori Yamashima
openalex   +1 more source