Results 21 to 30 of about 543,462 (281)

The Guanylyl Cyclase Activator YC-1 Directly Inhibits the Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells

Journal of Pharmacological Sciences, 2010
We investigated the effects of YC-1, an activator of soluble guanylyl cyclase (sGC), on voltage-dependent K+ (Kv) channels in smooth muscle cells from freshly isolated rabbit coronary arteries by using the whole-cell patch clamp technique. YC-1 inhibited
Won Sun Park, Jae-Hong Ko, Eun A Ko, Youn Kyoung Son, Da Hye Hong, In Duk Jung, Yeong-Min Park, Tae-Hoon Choi, Nari Kim, Jin Han   +9 more
doaj   +1 more source

Mitochondrial Dynamics in Mitochondrial Diseases

Diseases, 2016
Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals. Mitochondrial dynamics, including mitochondrial fission/fusion, movements and turnover, are essential for the mitochondrial network quality control.
Juan Suárez-Rivero, Marina Villanueva-Paz, Patricia De la Cruz-Ojeda, Mario De la Mata, David Cotán, Manuel Oropesa-Ávila, Isabel De Lavera, Mónica Álvarez-Córdoba, Raquel Luzón-Hidalgo, José Sánchez-Alcázar   +9 more
openaire   +3 more sources

Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease

Frontiers in Cell and Developmental Biology, 2021
Cardiovascular diseases are one of the leading causes of death and global health problems worldwide. Multiple factors are known to affect the cardiovascular system from lifestyles, genes, underlying comorbidities, and age.
Kai-Lieh Lin, Kai-Lieh Lin, Shang-Der Chen, Shang-Der Chen, Shang-Der Chen, Kai-Jung Lin, Chia-Wei Liou, Chia-Wei Liou, Chia-Wei Liou, Yao-Chung Chuang, Yao-Chung Chuang, Yao-Chung Chuang, Pei-Wen Wang, Pei-Wen Wang, Jiin-Haur Chuang, Jiin-Haur Chuang, Tsu-Kung Lin, Tsu-Kung Lin, Tsu-Kung Lin   +18 more
doaj   +1 more source

Mitochondrial Disease

Disease and Molecular Medicine, 2013
Pls see PDF.
Bulent Kurt, Turgut Topal
openaire   +2 more sources

Oral delivery of carrier-free dual-drug nanocrystal self-assembled microspheres improved NAD+ bioavailability and attenuated cardiac ischemia/reperfusion injury in mice

Drug Delivery, 2021
Nicotinamide riboside (NR), as a dietary supplement, can be converted to nicotinamide adenine dinucleotide (NAD+) in cells to support mitochondrial energy metabolism.
Hongfei Nie, Yarong Zhang, Haiyang Yu, Hong Xiao, Tao Li, Qian Yang   +5 more
doaj   +1 more source

A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

Marine Drugs, 2018
Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim, Sung Woo Cho, Hye Jin Heo, Seung Hun Jeong, Min Kim, Kyung Soo Ko, Byoung Doo Rhee, Natalia P. Mishchenko, Elena A. Vasileva, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han   +11 more
doaj   +1 more source

Mitochondrial Diseases

Journal of Epilepsy Research, 1970
Mitochondria contain the respiratory chain enzyme complexes that carry out oxidative phosphorylation and produce the main part of cellular energy in the form of ATP. Although several proteins related with signalling, assembling, transporting, and enzymatic function can be impaired in mitochondrial diseases, most frequently the activity of the ...
openaire   +2 more sources

Mitochondrial Diseases: Therapeutic Approaches

Bioscience Reports, 2007
Therapy of mitochondrial encephalomyopathies (defined restrictively as defects of the mitochondrial respiratory chain) is woefully inadequate, despite great progress in our understanding of the molecular bases of these disorders. In this review, we consider sequentially several different therapeutic approaches.
DiMauro S., Mancuso M.
openaire   +2 more sources

Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response

Biology, 2019
The rate of biological aging varies cyclically and episodically in response to changing environmental conditions and the developmentally-controlled biological systems that sense and respond to those changes.
Robert K. Naviaux
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source