Results 21 to 30 of about 10,242,723 (401)

Correction to: Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence

Translational Psychiatry, 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01239 ...
Roel J. T. Mocking, Jane C. Naviaux, Kefeng Li, Lin Wang, Jonathan M. Monk, A. Taylor Bright, Caroline A. Figueroa, Aart H. Schene, Henricus G. Ruhé, Johanna Assies, Robert K. Naviaux   +10 more
doaj   +1 more source

Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence

Translational Psychiatry, 2021
Recurrent major depressive disorder (rMDD) is a relapsing-remitting disease with high morbidity and a 5-year risk of recurrence of up to 80%. This was a prospective pilot study to examine the potential diagnostic and prognostic value of targeted plasma ...
Roel J. T. Mocking, Jane C. Naviaux, Kefeng Li, Lin Wang, Jonathan M. Monk, A. Taylor Bright, Caroline A. Figueroa, Aart H. Schene, Henricus G. Ruhé, Johanna Assies, Robert K. Naviaux   +10 more
doaj   +1 more source

Endocrine Manifestations and New Developments in Mitochondrial Disease

Endocrine reviews, 2021
Mitochondrial diseases are a group of common inherited diseases causing disruption of oxidative phosphorylation. Some patients with mitochondrial disease have endocrine manifestations, with diabetes mellitus being predominant but also include ...
Y. Ng, A. Lim, G. Panagiotou, D. Turnbull, M. Walker   +4 more
semanticscholar   +1 more source

Mitochondrial dynamics in health and disease: mechanisms and potential targets

Signal Transduction and Targeted Therapy, 2023
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature.
Wen Chen, Huakan Zhao, Yongsheng Li
semanticscholar   +1 more source

Metabolic features of treatment-refractory major depressive disorder with suicidal ideation

Translational Psychiatry, 2023
Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal ideation, and to identify individualized differences for personalized care.
Lisa A. Pan, Jane C. Naviaux, Lin Wang, Kefeng Li, Jonathan M. Monk, Sai Sachin Lingampelly, Anna Maria Segreti, Kaitlyn Bloom, Jerry Vockley, Mark A. Tarnopolsky, David N. Finegold, David G. Peters, Robert K. Naviaux   +12 more
doaj   +1 more source

Improved Dried Blood Spot-Based Metabolomics: A Targeted, Broad-Spectrum, Single-Injection Method

Metabolites, 2020
Dried blood spots (DBS) have proven to be a powerful sampling and storage method for newborn screening and many other applications. However, DBS methods have not yet been optimized for broad-spectrum targeted metabolomic analysis.
Kefeng Li, Jane C. Naviaux, Jonathan M. Monk, Lin Wang, Robert K. Naviaux   +4 more
doaj   +1 more source

Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

Nature Communications, 2020
Electron transport chain (ETC) defects occurring from mitochondrial disease mutations compromise ATP synthesis and render cells vulnerable to nutrient and oxidative stress conditions.
E. Balsa, E. Perry, C. Bennett, Mark P. Jedrychowski, S. Gygi, John G Doench, P. Puigserver   +6 more
semanticscholar   +1 more source

Metabolic effects of bezafibrate in mitochondrial disease

EMBO Molecular Medicine, 2020
Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial biogenesis with bezafibrate improves mitochondrial function in animal models, but there are no comparable human studies. We performed an open‐label observational experimental
H. Steele, A. Gomez-Duran, A. Pyle, S. Hopton, J. Newman, R. Stefanetti, S. Charman, J. Parikh, Langping He, C. Viscomi, D. Jakovljevic, K. Hollingsworth, A. Robinson, Robert W. Taylor, L. Bottolo, R. Horvath, P. Chinnery   +16 more
semanticscholar   +1 more source

Safety of drug use in patients with a primary mitochondrial disease: An international Delphi‐based consensus

Journal of Inherited Metabolic Disease, 2020
Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary withholding of a drug in a ...
M. D. De Vries, David A. Brown, Mitchell E. Allen, L. Bindoff, G. Gorman, A. Karaa, Nandaki Keshavan, C. Lamperti, R. Mcfarland, Y. Ng, M. O’Callaghan, R. Pitceathly, S. Rahman, F. Russel, K. N. Varhaug, T. Schirris, M. Mancuso   +16 more
semanticscholar   +1 more source

Mitochondrial diseases in adults [PDF]

Journal of Internal Medicine, 2020
AbstractMitochondrial medicine is a field that expanded exponentially in the last 30 years. Individually rare, mitochondrial diseases as a whole are probably the most frequent genetic disorder in adults. The complexity of their genotype–phenotype correlation, in terms of penetrance and clinical expressivity, natural history and diagnostic algorithm ...
La Morgia C., Maresca A., Caporali L., Valentino M. L., Carelli V.   +4 more
openaire   +3 more sources