Results 61 to 70 of about 5,164,021 (213)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mitochondrial DNA Backgrounds Might Modulate Diabetes Complications Rather than T2DM as a Whole [PDF]

, 2011
Mitochondrial dysfunction has been implicated in rare and common forms of type 2 diabetes (T2DM). Additionally, rare mitochondrial DNA (mtDNA) mutations have been shown to be causal for T2DM pathogenesis.
Baharak Hooshiar Kashani, Antonella Cormio, TORRONI A., Pala M., MARRA M, Santoro Aurelia, Lancioni, Hovirag, ACHILLI A, Viola Grugni, Lancioni Hovirag, Grugni V., Cormio Antonella, Sirolla, Cristina, GRUGNI V, Anna Olivieri, Franceschi Claudio, Spazzafumo L., Cormio, Antonella, Testa Roberto, SIROLLA C, Torroni, Antonio, Ugo A. Perego, Hooshiar Kashani, Baharak, PEREGO UA, Boemi, Massimo, Grugni Viola, Olivieri Anna, Grugni, Viola, Hooshiar Kashani Baharak, Gadaleta Maria Nicola, Testa I., Bonfigli, Anna Rita, Vincenza Battaglia, PEREGO, UGO ALESSANDRO, Achilli A., Roberto Testa, Achilli A1, GANDINI F, TESTA I, Antonio Ceriello, Pala Maria, Gandini Francesca, TESTA R, Marra M., Spazzafumo, Liana, Testa R., Testa, Roberto, Semino Ornella, Marra, Maurizio, Carossa Valeria, Anna Rita Bonfigli, Cormio A, SPAZZAFUMO L, Maria Pala, Olivieri A., Ivano Testa, Olivieri, Anna, BOEMI M, Marra Maurizio, Perego, Ugo A., SANTORO A, SEMINO O, Achilli Alessandro, HOOSHIAR KASHANI B, Boemi M., Spazzafumo Liana, Battaglia V., Hooshiar Kashani B., Testa, Ivano, Aurelia Santoro, Torroni Antonio, Ceriello, Antonio, Boemi Massimo, Massimo Boemi, Valeria Carossa, Bonfigli A. R., LANCIONI H, Gandini, Francesca, Sirolla Cristina, Battaglia Vincenza, Gadaleta, Maria Nicola, BATTAGLIA V, Sirolla C., Santoro, Aurelia, Bonfigli Anna Rita, Gadaleta M. N., Ceriello A., Carossa, Valeria, CAROSSA V, Pala, Maria, FRANCESCHI C, Semino O., Ceriello Antonio, Ugo A Perego, Antonio Torroni, Maria Nicola Gadaleta, Testa Ivano, Perego U. A., BONFIGLI AR, Ornella Semino, Franceschi, Claudio, Maurizio Marra, Hovirag Lancioni, Battaglia, Vincenza, Achilli, Alessandro, Semino, Ornella, CERIELLO A, GADALETA MN, Francesca Gandini, PALA M, Carossa V., Cormio A., Lancioni H., OLIVIERI A, Perego Ugo A., Alessandro Achilli, Claudio Franceschi, Gandini F., Cristina Sirolla, Liana Spazzafumo   +119 more
core   +2 more sources

Experimental Relocation of the Mitochondrial ATP9 Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution [PDF]

, 2012
Only a few genes remain in the mitochondrial genome retained by every eukaryotic organism that carry out essential functions and are implicated in severe diseases.
Tetaud, Emmanuel, Clauder-Münster, Sandra, di Rago, Jean-Paul, Giraud, Marie-France, Salin, Bénédicte, Godard, Franc¸ois, Sagot, Isabelle, Hermann-Le Denmat, Sylvie, Martos, Alexandre, Steinmetz, Lars M., Sellem, Carole H, Sainsard-Chanet, Annie, Contamine, Veronique, Bietenhader, Mailis, Kucharczyk, Roza, Aiyar, Raeka S, Dequard-Chablat, Michelle, Gagneur, Julien   +17 more
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction [PDF]

, 2009
Mitochondrial dysfunction is thought to contribute to neurodegenerative processes. As an example, dysfunction of complex I of the electron transport chain has been observed in Parkinson’s disease patients and 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (
Burté, F, Burte, Florence
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Primary skin fibroblasts as a model of Parkinson's disease [PDF]

, 2012
Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease.
Morales-Gordo, B., Jendrach, M., Heinz Reichmann, Brandt, Ulrich, Reichmann, H., Michael Klinkenberg, Jessica Drost, Morales-Gordo, Blas, Auburger, Georg, Blas Morales-Gordo, Vania Broccoli, Brandt, U., Marina Jendrach, Marcus, K., Klinkenberg, Michael, Auburger, G., Gispert, Suzana, Broccoli, Vania, Suzana Gispert, Marcus, Katrin, Ulrich Brandt, Jendrach, Marina, Wolfram S. Kunz, Klinkenberg, M., Drost, Jessica, Georg Auburger, Kunz, Wolfram S., Gispert, S., Kunz, W.S., Katrin Marcus, Droste, J.A.H., Broccoli, V., Reichmann, Heinz   +32 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity [PDF]

, 2009
Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors ...
Achilli Alessandro, GHELLI, ANNA MARIA, Mattioli Stefano, Pala M., Barbieri, Anna, Vidoni S., Torroni Antonio, Carelli Valerio, Anna Barbieri, Vidoni, Sara, Valerio Carelli, Carelli, Valerio, Ghelli, Anna, Mattioli, Stefano, Torroni, Antonio, Iommarini, Luisa, Zanna, Claudia, Pala, Maria, Vidoni Sara, Stefano Mattioli, Antonio Torroni, Achilli A., ZANNA C, Porcelli Anna Maria, Zanna Claudia, Pala Maria, MATTIOLI S, Luisa Iommarini, GHELLI A, Achilli, Alessandro, IOMMARINI L, Rugolo, Michela, Torroni A., Porcelli, Anna Maria, CARELLI V., Ghelli Anna, Rugolo Michela, BARBIERI A, RUGOLO M, PORCELLI AM, Anna Ghelli, Barbieri Anna, Sara Vidoni, Maria Pala, Alessandro Achilli, Anna Maria Porcelli, Michela Rugolo, Claudia Zanna, Iommarini Luisa, VIDONI S   +49 more
core   +1 more source