Results 81 to 90 of about 9,815,793 (361)
Marine Drugs, 2018 Doxorubicin, an anthracycline from Streptomyces peucetius, exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing increases in intracellular reactive oxygen species in the heart.
Chang Shin Yoon +6 more
doaj +1 more source
Mitochondria: Physiology & PathologyAn Insight into the Less Known Entity [PDF]
National Journal of Laboratory Medicine, 2013 Mitochondria are the small cellular organelle, considered to be the powerhouse or batteries of the cell. Unlike other organelles, they are unique due to the special characteristics they possess.
Huchanahalli Sheshanna Sreeshyla +4 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Echinochrome A Improves Exercise Capacity during Short-Term Endurance Training in Rats
Marine Drugs, 2015 Echinochrome A (Echi A) improves mitochondrial function in the heart; however, its effects on skeletal muscle are still unclear. We hypothesized that Echi A administration during short-term exercise may improve exercise capacity. Twenty-four male Sprague-
Dae Yun Seo +7 more
doaj +1 more source
PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes
Life Science Alliance, 2018 This work demonstrates that pathogenic variants in PISD cause mitochondrial disease and suggests a novel mechanistic link whereby impaired lipid content in the inner mitochondrial membrane alters the activity of inner mitochondrial membrane proteases ...
Tian Zhao +18 more
semanticscholar +1 more source
Mitochondrial DNA and Disease [PDF]
Annals of Medicine, 1997 Mitochondrial diseases are a group of disorders characterized by morphological or functional defects of the mitochondria, the organelles producing most of our cellular energy. As the only extranuclear site carrying genetic information, the mitochondria add an important chapter into the inheritance patterns of genetic diseases. Mitochondrial DNA (mtDNA)
openaire +2 more sources
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Mitochondrial Disease and Stroke [PDF]
Stroke, 2001 It is well known that some mitochondrial disorders are responsible for ischemic cerebral infarction in young patients. Our purpose was to determine, in this prospective ongoing study, whether ischemic stroke is the only manifestation of a mitochondrial disorder in young patients.Patients aged
Isabel Aguilera +8 more
openaire +3 more sources
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
Current opinion in pediatrics, 2018 Purpose of review Primary mitochondrial disease (PMD) is a genetically and phenotypically diverse group of inherited energy deficiency disorders caused by impaired mitochondrial oxidative phosphorylation (OXPHOS) capacity.
E. McCormick +2 more
semanticscholar +1 more source