Results 161 to 170 of about 10,033,806 (381)

A Novel TTC19 Mutation in a Patient With Neurological, Psychological, and Gastrointestinal Impairment

Frontiers in Neurology, 2019
Mitochondrial complex III deficiency nuclear type 2 is an autosomal-recessive disorder caused by mutations in TTC19 gene. TTC19 is involved in the preservation of mitochondrial complex III, which is responsible for transfer of electrons from reduced ...
Parham Habibzadeh, Parham Habibzadeh, Soroor Inaloo, Mohammad Silawi, Hassan Dastsooz, Hassan Dastsooz, Mohammad Ali Farazi Fard, Forough Sadeghipour, Zahra Faghihi, Mohaddeseh Rezaeian, Majid Yavarian, Johann Böhm, Mohammad Ali Faghihi, Mohammad Ali Faghihi   +13 more
doaj   +1 more source

Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer’s disease [PDF]

, 1999
Sayaka Ito, Shigeo Ohta, Kiyomi Nishimaki, Yasuo Kagawa, Rika Soma, Shinya Kuno, Yasuko Komatsuzaki, Hidehiro Mizusawa, Jun‐Ichi Hayashi   +8 more
openalex   +1 more source

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases [PDF]

, 2018
Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is
Adam-Vizi, V, Ankarcrona, M, Bano, D, Bazan, NG, Bernardi, P, Bolaños, JP, Connolly, NMC, Culmsee, C, Dawson, VL, Deshmukh, M, Duchen, MR, Düssmann, H, Fiskum, G, Galindo, MF, Gioran, A, Hardingham, GE, Hardwick, JM, Jekabsons, MB, Jonas, EA, Jordán, J, Joselin, A, Lipton, SA, Llorente-Folch, I, Manfredi, G, Mattson, MP, McLaughlin, B, Methner, A, Moreira Pinho, C, Murphy, AN, Murphy, MP, Nicholls, DG, Park, DS, Pizzo, P, Polster, BM, Pozzan, T, Prehn, JHM, Rizzuto, R, Salvucci, M, Satrústegui, J, Slack, RS, Swanson, RA, Swerdlow, RH, Theurey, P, Watters, O, Will, Y, Ying, Z   +45 more
core  

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Plasma LDH: A specific biomarker for lung affectation in COVID-19?

Practical Laboratory Medicine, 2021
Objectives: We aimed to determine whether the plasma profile of lactate dehydrogenase (LDH) isoenzymes is altered in patients with COVID-19, and whether this is attributable to a specific release of LDH-3, the main LDH isoenzyme expressed in lungs ...
Pablo Serrano-Lorenzo, Olga N. Coya, Ana López-Jimenez, Alberto Blázquez, Aitor Delmiro, Alejandro Lucia, Joaquín Arenas, Miguel A. Martín, Alejandro Santos-Lozano, Cecilia Cueto-Felgueroso, Alba Fernández-del Pozo, Montserrat de Miguel-Reyes   +11 more
doaj  

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry1

Journal of Lipid Research, 2010
An improved high-performance liquid chromatography-mass spectrometry method for the separation and characterization of cardiolipin molecular species is presented.
Paul E. Minkler, Charles L. Hoppel
doaj  

Targeting DNM1L/DRP1-FIS1 axis inhibits high-grade glioma progression by impeding mitochondrial respiratory cristae remodeling

Journal of Experimental & Clinical Cancer Research
Background The dynamics of mitochondrial respiratory cristae (MRC) and its impact on oxidative phosphorylation (OXPHOS) play a crucial role in driving the progression of high-grade glioma (HGG). However, the underlying mechanism remains unclear.
Xiaodong Li, Jingjing Tie, Yuze Sun, Chengrong Gong, Shizhou Deng, Xiyu Chen, Shujiao Li, Yaoliang Wang, Zhenhua Wang, Feifei Wu, Hui Liu, Yousheng Wu, Guopeng Zhang, Qingdong Guo, Yanling Yang, Yayun Wang   +15 more
doaj   +1 more source

Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review

EBioMedicine, 2022
Summary: Background: Mitochondrial DNA (mtDNA) encodes 37 genes necessary for synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA alterations are known to cause mitochondrial disease (MitD), a clinically heterogeneous group
Alba Valiente-Pallejà, Juan Tortajada, Bengisu K. Bulduk, Elisabet Vilella, Glòria Garrabou, Gerard Muntané, Lourdes Martorell   +6 more
doaj  

Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance

FEBS Open Bio, EarlyView.
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley   +1 more source