Results 181 to 190 of about 742,356 (291)

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, EarlyView.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source

Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase. [PDF]

Sci Adv
Hu Z, Yu J, Liu Z, Jiang M, Zeng AP.
europepmc   +1 more source

Animal Models of Mitochondrial Diseases Associated with Nuclear Gene Mutations. [PDF]

Acta Naturae, 2023
Averina OA, Kuznetsova SA, Permyakov OA, Sergiev PV.   +3 more
europepmc   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Diagnosis of pediatric mitochondrial diseases via targeted next-generation sequencing (NGS): real-world data with the Blueprint Genetics^® platform. [PDF]

Orphanet J Rare Dis
Sapuppo A, Privitera GF, Sortino V, Pavone P, Polizzi A, Ruggieri M, Falsaperla R.   +6 more
europepmc   +1 more source

Adrenal Dysfunction in Mitochondrial Diseases. [PDF]

Int J Mol Sci, 2023
Corkery-Hayward M, Metherell LA.
europepmc   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Accelerate the discovery of genetic variants in mitochondrial diseases with Variant prIOritization using Latent spAce. [PDF]

Brief Bioinform
Labory J, Boulaimen Y, Singh J, Ait-El-Mkadem Saadi S, Paquis-Flucklinger V, Bannwarth S, Bottini S.   +6 more
europepmc   +1 more source

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Phase separation in mitochondrial fate and mitochondrial diseases. [PDF]

Proc Natl Acad Sci U S A
Chen Q, An S, Wang C, Zhou Y, Liu X, Ren W.   +5 more
europepmc   +1 more source