Results 1 to 10 of about 3,599,306 (248)

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Experimental and Molecular Medicine, 2023
Inflammatory diseases: Understanding mitochondrial DNA release Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeonghan Kim, Ho-Shik Kim, Jay H. Chung
doaj   +2 more sources

The Mitochondrial Response to DNA Damage

Frontiers in Cell and Developmental Biology, 2021
Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong, Peipei Tu, Peiqi Xu, Yan Sun, Fangfang Yu, Na Tu, Lixia Guo, Yanan Yang   +7 more
doaj   +2 more sources

Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness

bioRxiv, 2023
Somatic variation contributes to biological heterogeneity by modulating cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor ...
Caleb A. Lareau, Yajie Yin, Jacob C. Gutierrez, R. Dhindsa, Anne-Sophie Gribling-Burrer, Yu-Hsin Hsieh, Lena Nitsch, Frank A Buquicchio, Tsion Abay, Sebastian Zielinski, Robert R. Stickels, Jacob C. Ulirsch, Patrick K. Yan, Fangyi Wang, Zhuang Miao, Katalin D. Sandor, Bence Dániel, Vincent Liu, Quanli Wang, Fengyuan Hu, Katherine R Smith, S. V. Deevi, P. Maschmeyer, S. Petrovski, R. Smyth, William J. Greenleaf, Anshul B Kundaje, Mathias Munschauer, Leif S. Ludwig, Ansuman T. Satpathy   +29 more
semanticscholar   +1 more source

Effective differentiation of double negative thymocytes requires high fidelity replication of mitochondrial DNA in an age dependent manner

Frontiers in Immunology, 2023
One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes.
Candice B. Limper, Narda Bondah, Daphne Zhu, Alanis N. Villanueva, Uchenna K. Chukwukere, Weishan Huang, Weishan Huang, Avery August, Avery August   +8 more
doaj   +1 more source

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

bioRxiv, 2023
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of mtDNA detection by cytosolic nucleic acid sensors remain poorly defined.
Yuanjiu Lei, Jordyn J. VanPortfliet, Yi-fan Chen, J. D. Bryant, Y. Li, Danielle Fails, S. Torres-Odio, Katherine B. Ragan, Jingti Deng, Armaan Mohan, Bing Wang, Olivia N. Brahms, S. Yates, Michael Spencer, C. Tong, M. Bosenberg, L. C. West, G. Shadel, T. Shutt, J. Upton, Pingwei Li, A. West   +21 more
semanticscholar   +1 more source

Whole-Exome Sequencing Identifies a Novel POLG Frameshift Variant in an Adult Patient Presenting with Progressive External Ophthalmoplegia and Mitochondrial DNA Depletion

Case Reports in Genetics, 2021
Mitochondrial DNA (mtDNA) depletion syndromes are a group of autosomal recessive disorders associated with a spectrum of clinical diseases, which include progressive external ophthalmoplegia (PEO).
Justin Kurtz, Joseph Americo Fernandes, Mahesh Mansukhani, William C. Copeland, Ali B. Naini   +4 more
doaj   +1 more source

The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome

Biomolecules, 2023
Nuclear-mitochondrial DNA segments (NUMTs) are mitochondrial DNA (mtDNA) fragments that have been inserted into the nuclear genome. Some NUMTs are common within the human population but most NUMTs are rare and specific to individuals. NUMTs range in size
Liying Xue, Jesse D. Moreira, Karan K. Smith, Jessica L. Fetterman   +3 more
doaj   +1 more source

35 Years of TFAM Research: Old Protein, New Puzzles

Biology, 2023
Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells.
Natalya Kozhukhar, Mikhail F. Alexeyev
doaj   +1 more source

Whole Mitochondrial Genome Analysis in Turkish Patients With Mitochondrial Diseases

Balkan Medical Journal, 2022
Background: Mitochondrial diseases are a clinically heterogeneous group of rare hereditary disorders that are defined by a genetic defect predominantly affecting mitochondrial oxidative phosphorylation.
Emine Begüm Gencer Öncül, Duygu Duman, Fatma Tuba Eminoğlu, Süleyman Aktuna, Mustafa Türker Duman   +4 more
doaj   +1 more source

Caenorhabditis elegans as a model system for studying drug induced mitochondrial toxicity [PDF]

, 2015
Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake of antiretroviral drugs however, leads to severe and even life-threatening side effects ...
Brul, Stanley, de Boer, Richard, De Vos, Winnok, Manders, Erik MM, Smith, Ruben L, van der Spek, Hans   +5 more
core   +11 more sources