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Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine, 2023 Inflammatory diseases: Understanding mitochondrial DNA release Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeonghan Kim, Ho-Shik Kim, Jay H. Chung
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The Mitochondrial Response to DNA Damage
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are double membrane organelles in eukaryotic cells that provide energy by generating adenosine triphosphate (ATP) through oxidative phosphorylation. They are crucial to many aspects of cellular metabolism.
Ziye Rong +7 more
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Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans
Nature Communications, 2020 Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can ...
Wei Wei +15 more
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Mitochondrial DNA: the overlooked oncogenome? [PDF]
BMC Biology, 2019 Perturbed mitochondrial bioenergetics constitute a core pillar of cancer-associated metabolic dysfunction. While mitochondrial dysfunction in cancer may result from myriad biochemical causes, a historically neglected source is that of the mitochondrial ...
P. Gammage, C. Frezza
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Rapid evolution of animal mitochondrial DNA. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1979 W. Brown, M. George, A. Wilson
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Codon affinity in mitochondrial DNA shapes evolutionary and somatic fitness
bioRxiv, 2023 Somatic variation contributes to biological heterogeneity by modulating cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor ...
Caleb A. Lareau +29 more
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Frontiers in Immunology, 2023 One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes.
Candice B. Limper +8 more
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Case Reports in Genetics, 2021 Mitochondrial DNA (mtDNA) depletion syndromes are a group of autosomal recessive disorders associated with a spectrum of clinical diseases, which include progressive external ophthalmoplegia (PEO).
Justin Kurtz +4 more
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The Mighty NUMT: Mitochondrial DNA Flexing Its Code in the Nuclear Genome
Biomolecules, 2023 Nuclear-mitochondrial DNA segments (NUMTs) are mitochondrial DNA (mtDNA) fragments that have been inserted into the nuclear genome. Some NUMTs are common within the human population but most NUMTs are rare and specific to individuals. NUMTs range in size
Liying Xue +3 more
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Whole Mitochondrial Genome Analysis in Turkish Patients With Mitochondrial Diseases
Balkan Medical Journal, 2022 Background: Mitochondrial diseases are a clinically heterogeneous group of rare hereditary disorders that are defined by a genetic defect predominantly affecting mitochondrial oxidative phosphorylation.
Emine Begüm Gencer Öncül +4 more
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