Results 21 to 30 of about 582,066 (267)

A rapid and efficient method for enriching mitochondrial DNA from plants

open access: yesMitochondrial DNA. Part B. Resources, 2018
Current mitochondrial purification techniques are tedious and protracted due to their emphasis on recovering physiologically active mitochondria. However, for studies that are exclusively interested in isolating mitochondrial DNA (mtDNA) for applications
Mackenzie M. Strehle   +2 more
doaj   +1 more source

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?

open access: yesCells, 2022
Mitochondria are well known as ‘the powerhouses of the cell’. Indeed, their major role is cellular energy production driven by both mitochondrial and nuclear DNA.
Amira Podolak   +2 more
doaj   +1 more source

Defects of Mitochondrial DNA

open access: yesBrain Pathology, 1992
In the past few years several syndromes have been associated with lesions of the human mitochondrial DNA. MtDNA is a small, circular extra‐nuclear chromosome encoding essential components of the respiratory chain. MtDNA‐related syndromes can be divided into two groups: mitochondrial encephalomyopathies, characterized by the presence of ragged‐red ...
Zeviani M., Antozzi C.
openaire   +2 more sources

Structure–Function Analysis Reveals the Singularity of Plant Mitochondrial DNA Replication Components: A Mosaic and Redundant System

open access: yesPlants, 2019
Plants are sessile organisms, and their DNA is particularly exposed to damaging agents. The integrity of plant mitochondrial and plastid genomes is necessary for cell survival.
Luis Gabriel Brieba
doaj   +1 more source

A new method for long-read sequencing of animal mitochondrial genomes: application to the identification of equine mitochondrial DNA variants

open access: yesBMC Genomics, 2020
Background Mitochondrial DNA is remarkably polymorphic. This is why animal geneticists survey mitochondrial genomes variations for fundamental and applied purposes.
Sophie Dhorne-Pollet   +2 more
doaj   +1 more source

Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases

open access: yesNeural Regeneration Research
The mitochondrial genomic homeostasis is essential for the function of the oxidative phosphorylation system and cellular homeostasis. Mitochondrial DNA is particularly susceptible to aging-related oxidative stress due to the lack of a histone coat ...
Tingting Fu   +5 more
doaj   +1 more source

Commentary of "The Use of Mitochondrial Replacement in IVF: A Call for Expansion"

open access: yesVoices in Bioethics, 2014
by Lillian Ringel • Briana’s op-ed calling for expansion of mitochondrial DNA replacement in IVF was an interesting read.  She starts her op-ed with a description of what mitochondrial DNA is, and though it may seem rudimentary to some, since I have a
Lillian Ringel, Amy Scharf
doaj   +1 more source

Complete mitochondrial genomes of two marine monogonont rotifer Brachionus manjavacas strains

open access: yesMitochondrial DNA. Part B. Resources, 2021
The complete mitochondrial genomes of Brachionus manjavacas German strain were 10,721 bp (mitochondrial DNA I) and 12,274 bp (mitochondrial DNA II) in size, while the complete mitochondrial genomes of B.
Min-Sub Kim   +7 more
doaj   +1 more source

Mitochondrial DNA and ageing

open access: yesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 2006
The accumulation of mitochondrial DNA mutations has been proposed as a potential mechanism in the physiological processes of ageing and age-related disease. Although mitochondria have long been anticipated as a perpetrator of ageing, there was little experimental evidence to link these changes directly with the cellular pathology of ageing.
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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