Results 181 to 190 of about 920,301 (294)

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il. Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Caloric restriction enhances inheritance of wild-type mitochondrial DNA in Saccharomyces cerevisiae. [PDF]

Sci Rep
Zhu W, Yoshida M, Ling F.
europepmc   +1 more source

eCOMPAGT integrates mtDNA: import, validation and export of mitochondrial DNA profiles for population genetics, tumour dynamics and genotype-phenotype association studies [PDF]

, 2010
Hansi Weißensteiner, Sebastian Schönherr, Günther Specht, Florian Kronenberg, Anita Kloss‐Brandstätter   +4 more
openalex   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target. [PDF]

Antioxidants (Basel)
Xiang M, Yang M, Zhang L, Ouyang X, Sarapultsev A, Luo S, Hu D.   +6 more
europepmc   +1 more source

Measures of DNA polymorphism and neutrality tests (Tajima's D and Fu's Fs tests) for nuclear and mitochondrial DNA marker sequences of <i>Desmophyllum dianthus</i> specimens.

, 2015
M. Addamo Anna, Danielle R. James, Taviani Marco, Freiwald Andrè, Machordom Annie   +4 more
openalex   +2 more sources

Abstract 1912: Retinoid x Receptor Alpha DNA Binding for Mitochondrial Transcription

, 2023
James Weiser, Megan Bestwick
openalex   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Author Correction: Ribonucleotide incorporation into mitochondrial DNA drives inflammation. [PDF]

Nature
Bahat A, Milenkovic D, Cors E, Barnett M, Niftullayev S, Katsalifis A, Schwill M, Kirschner P, MacVicar T, Giavalisco P, Jenninger L, Clausen AR, Paupe V, Prudent J, Larsson NG, Rogg M, Schell C, Muylaert I, Larsson E, Nolte H, Falkenberg M, Langer T.   +21 more
europepmc   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source