Results 11 to 20 of about 3,268,780 (386)

Evidence for variation in the effective population size of animal mitochondrial DNA [PDF]

, 2009
Background: It has recently been shown that levels of diversity in mitochondrial DNA are remarkably constant across animals of diverse census population sizes and ecologies, which has led to the suggestion that the effective population of mitochondrial ...
A Eyre-Walker, A Eyre-Walker, Adam Eyre-Walker, B Nabholz, B Nabholz, CD Millar, CJ Mulligan, E Bazin, E Bazin, E Nevo, Gwenael Piganeau, J Maynard Smith, JD Thompson, JH Gillespie, JH Gillespie, JJ Welch, K Popadin, K Tamura, L Bromham, L Chao, M Albu, MC Whitlock, MJ Benton, N Bierne, N Galtier, Neil John Gemmell, PD Keightley, RC Lewontin, W Jia   +28 more
core   +12 more sources

35 Years of TFAM Research: Old Protein, New Puzzles

Biology, 2023
Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells.
Natalya Kozhukhar, Mikhail F. Alexeyev
doaj   +1 more source

Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

Genome Biology, 2020
Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan, Matthew J. Longley, Margaret H. Humble, Christopher A. Lavender, Adam Burkholder, Emma L. Blakely, Charlotte L. Alston, Grainne S. Gorman, Doug M. Turnbull, Robert McFarland, Robert W. Taylor, Thomas A. Kunkel, William C. Copeland   +12 more
doaj   +1 more source

Mitochondrial DNA Methylation and Human Diseases

International Journal of Molecular Sciences, 2021
Epigenetic modifications of the nuclear genome, including DNA methylation, histone modifications and non-coding RNA post-transcriptional regulation, are increasingly being involved in the pathogenesis of several human diseases.
Andrea Stoccoro, F. Coppedè
semanticscholar   +1 more source

Mitochondrial DNA in inflammation and immunity

EMBO Reports, 2020
Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation.
Joel S. Riley, S. Tait
semanticscholar   +1 more source

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

Molecules, 2023
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park, Noe Baruch-Torres, Y. Whitney Yin   +2 more
doaj   +1 more source

Mitochondrial DNA copy number in human disease: the more the better?

FEBS Letters, 2020
Most of the genetic information has been lost or transferred to the nucleus during the evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that is essential for oxidative phosphorylation (OXPHOS). In mammals, a gene‐dense
R. Filograna, M. Mennuni, David Alsina, N. Larsson   +3 more
semanticscholar   +1 more source

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Autophagy, 2020
Pancreatic cancer tends to be highly resistant to current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates.
Changfeng Li, Ying Zhang, Jiao Liu, R. Kang, D. Klionsky, D. Tang   +5 more
semanticscholar   +1 more source

Genome-wide characterization of mitochondrial DNA methylation in human brain

Frontiers in Endocrinology, 2023
BackgroundThere is growing interest in the role of DNA methylation in regulating the transcription of mitochondrial genes, particularly in brain disorders characterized by mitochondrial dysfunction.
Matthew Devall, Darren M. Soanes, Adam R. Smith, Emma L. Dempster, Rebecca G. Smith, Joe Burrage, Artemis Iatrou, Eilis Hannon, Claire Troakes, Karen Moore, Paul O’Neill, Safa Al-Sarraj, Leonard Schalkwyk, Jonathan Mill, Michael Weedon, Katie Lunnon   +15 more
doaj   +1 more source

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]

, 2004
Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H, Coenen, MJH, Heister, A, Newbold, RF, Rossi, R, Sasarman, F, Shoubridge, EA, Smeitink, JAM, Trijbels, FJMF, Ugalde, C, van den Heuvel, LP   +10 more
core   +4 more sources