Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine, 2023 Inflammatory diseases: Understanding mitochondrial DNA release Cytosolic DNA activates the cGAS-STING pathway which mediates inflammation and antiviral response. One source of cytosolic DNA is ‘self ‘ DNA, such as mitochondrial DNA.
Jeonghan Kim, Ho-Shik Kim, Jay H. Chung
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Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]
, 2004 Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H +10 more
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Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Clinical Epigenetics, 2017 Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases.
Matthew Devall +8 more
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Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report
Frontiers in Neurology, 2022 Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini +1 more
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
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Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
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Analysis of Nuclear Mitochondrial DNA Segments of Nine Plant Species: Size, Distribution, and Insertion Loci [PDF]
Genomics & Informatics, 2016 Nuclear mitochondrial DNA segment (Numt) insertion describes a well-known phenomenon of mitochondrial DNA transfer into a eukaryotic nuclear genome. However, it has not been well understood, especially in plants. Numt insertion patterns vary from species
Young-Joon Ko, Sangsoo Kim
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DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
Journal of Aging Research, 2011 During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
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Royal Society Open Science, 2021 After initial detection of target archival DNA of a 116-year-old syntype specimen of the smooth lantern shark, Etmopterus pusillus, in a single-stranded DNA library, we shotgun-sequenced additional 9 million reads from this same DNA library.
Nicolas Straube +3 more
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DNA-PKcs promotes sepsis-induced multiple organ failure by triggering mitochondrial dysfunction
Journal of Advanced Research, 2022 Introduction: Multiple organ failure is the commonest cause of death in septic patients. Objectives: This study was undertaken in an attempt to elucidate the functional importance of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on ...
Rongjun Zou +11 more
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