Mitochondrial DNA replacement versus nuclear DNA persistence [PDF]
, 2006 In this paper we consider two populations whose generations are not overlapping and whose size is large. The number of males and females in both populations is constant.
Maurizio Serva
openalex +3 more sources
Evidence for variation in the effective population size of animal mitochondrial DNA [PDF]
, 2009 Background: It has recently been shown that levels of diversity in mitochondrial DNA are remarkably constant across animals of diverse census population sizes and ecologies, which has led to the suggestion that the effective population of mitochondrial ...
A Eyre-Walker +28 more
core +12 more sources
Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
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Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
Clinical Epigenetics, 2017 Background DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases.
Matthew Devall +8 more
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Frontiers in Bioscience, 2017 Plants possess mitochondrial genomes that are large and complex compared to animals. Nearly all animal mitochondrial genomes are about 16.5. kbp in length, whereas plant mitochondrial genomes range between 200-2,000 kbp. This is curious if we assume modern mitochondria originated from a common alpha-proteobacterial ancestor.
Stewart A, Morley, Brent L, Nielsen
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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
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Neuropathic Pain as Main Manifestation of POLG-Related Disease: A Case Report
Frontiers in Neurology, 2022 Mutations in nuclear-encoded genes that are involved in mitochondrial DNA replication and maintenance (e.g., POLG) have been associated with chronic progressive external ophthalmoplegia (CPEO) phenotype.
Melanie Lang-Orsini +1 more
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Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]
, 2004 Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H +10 more
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Analysis of Nuclear Mitochondrial DNA Segments of Nine Plant Species: Size, Distribution, and Insertion Loci [PDF]
Genomics & Informatics, 2016 Nuclear mitochondrial DNA segment (Numt) insertion describes a well-known phenomenon of mitochondrial DNA transfer into a eukaryotic nuclear genome. However, it has not been well understood, especially in plants. Numt insertion patterns vary from species
Young-Joon Ko, Sangsoo Kim
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DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
Journal of Aging Research, 2011 During the last decades, our knowledge about the processes involved in the aging process has exponentially increased. However, further investigation will be still required to globally understand the complexity of aging.
Ricardo Gredilla
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