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Mitochondrial Dysfunction in Atherosclerosis
DNA and Cell Biology, 2019Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These components also play important roles in cell homeostasis by regulating cell function and phenotypic modulation. Atherosclerosis is the leading cause of morbidity and mortality in developed and developing countries.
Wenxi, Peng +7 more
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ApoE and mitochondrial dysfunction
Neurology, 2020Alzheimer disease (AD) is the leading cause of dementia in the elderly, affecting more than 5.4 million individuals in the United States. AD is associated with progressive neuronal loss in the cortex and hippocampus, accompanied by extracellular amyloid plaques containing amyloid-β (Aβ) deposits, and intracellular neurofibrillary tangles.
Lixia, Qin +2 more
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Mitochondrial dysfunction in reproduction
Mitochondrion, 2004The mitochondrial genome passes from one generation to the next by way of the egg's cytoplasm, so ordinarily an individual's mitochondrial DNA (mtDNA) is entirely derived from his or her mother. A potential mother has a finite number of eggs, or oocytes, all of which were formed when she herself was still a fetus, many years before she can conceive ...
Robert P S, Jansen, Graham J, Burton
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Mitochondrial Dysfunction in Schizophrenia
BioEssays, 2020AbstractSchizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly address negative symptoms and cognitive symptoms, warranting the development of better treatment options.
Peiyan Ni, Sangmi Chung
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Mitochondrial dysfunction and age
Current Opinion in Clinical Nutrition and Metabolic Care, 2007Mitochondrial dysfunction is commonly thought to result from oxidative damage that leads to defects in the electron transport chain (ETC). In this review, we highlight new research indicating that there are early changes in mitochondrial function that precede ETC defects and are reversible thereby providing the possibility of slowing the tempo of ...
Kevin E, Conley +2 more
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Mitochondrial Dysfunction during Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2010Sepsis and multiple organ failure remain leading causes of death in intensive care patients. Recent advances in our understanding of the pathophysiology of these syndromes include a likely prominent role for mitochondria. Patient studies have shown that the degree of mitochondrial dysfunction is related to the eventual outcome.
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Mitochondrial Dysfunction and Glaucoma
Journal of Glaucoma, 2009Glaucoma is increasingly recognized as a neurodegenerative disorder, characterized by the accelerated loss of retinal ganglion cells (RGCs) and their axons. Open angle glaucoma prevalence and incidence increase exponentially with increasing age, yet the pathophysiology underlying increasing age as a risk factor for glaucoma is not well understood ...
George Y X, Kong +3 more
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Mitochondrial Dysfunction in Autism
Seminars in Pediatric Neurology, 2013Using data of the current prevalence of autism as 200:10,000 and a 1:2000 incidence of definite mitochondrial (mt) disease, if there was no linkage of autism spectrum disorder (ASD) and mt disease, it would be expected that 1 in 110 subjects with mt disease would have ASD and 1 in 2000 individuals with ASD would have mt disease.
Agustín, Legido +2 more
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Mitochondrial dysfunction in osteoarthritis
Mitochondrion, 2004In osteoarthritis (OA) a time or age dependent process leads to aberrant cartilage structure which is characterized by reduced number of chondrocytes, loss of existing cartilage extracellular matrix, the production of matrix with abnormal composition and pathologic matrix calcification.
Francisco J, Blanco +2 more
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Mitochondrial Dysfunction in Epilepsy
Seminars in Pediatric Neurology, 2013Epilepsy is the most common neurologic disorder worldwide and is characterized by recurrent unprovoked seizures. The mitochondrial (mt) respiratory chain is the final common pathway for cellular energy production through the process of oxidative phosphorylation.
Divya S, Khurana +3 more
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