Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement [PDF]
Redox Biology, 2020 The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation.
Deirdre Nolfi-Donegan +2 more
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Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain [PDF]
Frontiers in Cell and Developmental Biology, 2020 Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette ...
Jacopo Junio Valerio Branca +5 more
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Lactate activates the mitochondrial electron transport chain independently of its metabolism. [PDF]
Mol Cell, 2023 Lactate has long been considered a cellular waste product. However, we found that as extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates mitochondrial electron transport chain (ETC) activity.
Cai X +6 more
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Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. [PDF]
Nat Immunol, 2022 The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including ...
Billingham LK +11 more
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Differential requirements for mitochondrial electron transport chain components in the adult murine liver. [PDF]
Elife, 2022 Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans, and displays striking tissue specificity depending on the affected gene.
Lesner NP +11 more
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Deletion of Von Willebrand A Domain Containing Protein (VWA8) raises activity of mitochondrial electron transport chain complexes in hepatocytes [PDF]
Biochemistry and Biophysics Reports, 2021 VWA8 (Von Willebrand A Domain Containing Protein 8) is a AAA+ ATPase that is localized to the mitochondrial matrix and is widely expressed in highly energetic tissues.
Moulun Luo +4 more
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SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. [PDF]
Sci Adv, 2020 A sulfide oxidase mediates therapeutic actions of H2S by targeting mitochondrial electron flow to induce mitochondrial uncoupling. Hydrogen sulfide (H2S) is a gasotransmitter and a potential therapeutic agent.
Jia J +15 more
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Mitochondrial electron transport chain, ROS generation and uncoupling (Review). [PDF]
Int J Mol Med, 2019 The mammalian mitochondrial electron transport chain (ETC) includes complexes I-IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and ...
Zhao RZ, Jiang S, Zhang L, Yu ZB.
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Structure and mechanism of mitochondrial electron transport chain
Biomedical Journal, 2018 Respiration is one of the most vital and basic features of living organisms. In mammals, respiration is accomplished by respiratory chain complexes located on the mitochondrial inner membrane.
Runyu Guo +4 more
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Stress signalling dynamics of the mitochondrial electron transport chain and oxidative phosphorylation system in higher plants. [PDF]
Ann Bot, 2020 BACKGROUND Mitochondria play a diversity of physiological and metabolic roles under conditions of abiotic or biotic stress. They may be directly subjected to physico-chemical constraints, and they are also involved in integrative responses to ...
Dourmap C +11 more
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