Results 101 to 110 of about 495,836 (314)

Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner

bioRxiv, 2017
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia in operating rooms and for sedation in intensive care units.
C. Sumi, A. Okamoto, Hiromasa Tanaka, K. Nishi, Munenori Kusunoki, Tomohiro Shoji, Takeo Uba, Y. Matsuo, T. Adachi, J. Hayashi, K. Takenaga, K. Hirota   +11 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex

Journal of Biological Chemistry, 2019
Three mitochondrial metabolic pathways are required for efficient energy production in eukaryotic cells: the electron transfer chain (ETC), fatty acid β-oxidation (FAO), and the tricarboxylic acid cycle.
Yudong Wang, J. Palmfeldt, N. Gregersen, A. Makhov, J. Conway, Meicheng Wang, Stephen McCalley, Shrabani Basu, Hana Alharbi, C. S. St Croix, Michael J. Calderon, Simon C Watkins, J. Vockley   +12 more
semanticscholar   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.

PLoS Genetics, 2016
Mitochondrial dysfunction underlies numerous age-related pathologies. In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C.
Erin Munkácsy, Maruf H Khan, Rebecca K Lane, Megan B Borror, Jae H Park, Alex F Bokov, Alfred L Fisher, Christopher D Link, Shane L Rea   +8 more
doaj   +1 more source

Modulation of Mitochondrial Bioenergetics in the Isolated Guinea Pig Beating Heart by Potassium and Lidocaine Cardioplegia: Implications for Cardioprotection [PDF]

, 2009
Mitochondria are damaged by cardiac ischemia/reperfusion (I/R) injury but can contribute to cardioprotection. We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against ...
Aldakkak, Mohammed, Camara, Amadou K.S., Chen, Qun, Heisner, James S., Lesnefsky, Edward J., Stowe, David F.   +5 more
core   +2 more sources

Diode-like behaviour of a mitochondrial electron-transport enzyme

Nature, 1992
In mitochondria, electrons derived from the oxidation of succinate by the tricarboxylic acid cycle enzyme succinate-ubiquinone oxido-reductase are transferred directly to the quinone pool. Here we provide evidence that the soluble form of this enzyme (succinate dehydrogenase) behaves as a diode that essentially allows electron flow in one direction ...
Sucheta, A, Ackrell, B, Cochran, B, Armstrong, F   +3 more
openaire   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The association of mitochondrial morphology and supercomplex redistribution with skeletal muscle oxidative capacity in older adults

Physiological Reports
Skeletal muscle maximal oxidative capacity (ATPmax) is a key component of age‐related sarcopenia and muscle health. The contribution of mitochondrial morphology and electron transport chain supercomplex (SC) assemblies to ATPmax has yet to be determined ...
Mauricio Castro Sepulveda, Sylviane Lagarrigue, Francesca Amati   +2 more
doaj   +1 more source

Structural determinants of mitochondrial STAT3 targeting and function

Mitochondrial Communications
Signal transducer and activator of transcription (STAT) 3 has been found within mitochondria in addition to its canonical role of shuttling between cytoplasm and nucleus during cytokine signaling.
Isabelle J. Marié, Tanaya Lahiri, Özlem Önder, Kojo S.J. Elenitoba-Johnson, David E. Levy   +4 more
doaj   +1 more source