Results 121 to 130 of about 495,836 (314)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Biological sex does not impact intrinsic mitochondrial respiration supported by complexes I and II in human skeletal muscle

Experimental Physiology
The effect of biological sex on rates of skeletal muscle mitochondrial respiration supported by creatine‐dependent phosphate shuttling was previously unknown.
Emily J. Ferguson, Lauren J. Pacitti, Justin Bureau, Callum J. Pufahl, Eveline Menezes, Tanner Stokes, Shivam Gandhi, Luca J. Delfinis, Craig A. Simpson, Christopher G. R. Perry, Brendon J. Gurd, Chris McGlory   +11 more
doaj   +1 more source

LC-MS proteomics analysis of the iInsulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism [PDF]

, 2014
The insulin/IGF-1 receptor is a major known determinant of dauer formation, stress resistance, longevity, and metabolism in Caenorhabditis elegans. In the past, whole-genome transcript profiling was used extensively to study differential gene expression ...
Braeckman, Bart, Brewer, Heather M, Camp, David G, II, Depuydt, Geert, Petyuk, Vladislav A, Smith, Richard D, Smolders, Arne, Xie, Fang   +7 more
core   +2 more sources

Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport

OncoTarget, 2016
Metformin displays antileukemic effects partly due to activation of AMPK and subsequent inhibition of mTOR signaling. Nevertheless, Metformin also inhibits mitochondrial electron transport at complex I in an AMPK-independent manner, Here we report that ...
J. Velez, Rongqing Pan, Jason T. C. Lee, L. Enciso, Marta Suarez, Jorge Eduardo Duque, Daniel Jaramillo, C. López, L. Morales, W. Bornmann, M. Konopleva, G. Krystal, M. Andreeff, I. Samudio   +13 more
semanticscholar   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Characterization of Translocation Contact Sites Involved in the Import of Mitochondrial Proteins [PDF]

, 1987
Import of proteins into the mitochondrial matrix requires translocation across two membranes. Translocational intermediates of mitochondrial proteins, which span the outer and inner membrane simultaneously and thus suggest that translocation occurs in ...
Herzog, Volker, Neupert, Walter, Schwaiger, Martin   +2 more
core   +3 more sources

Insights into the post-transcriptional regulation of the mitochondrial electron transport chain

Biochemical Society Transactions, 2016
The regulation of the mitochondrial electron transport chain is central to the control of cellular homeostasis. There are significant gaps in our understanding of how the expression of the mitochondrial and nuclear genome-encoded components of the ...
Tamara M. Sirey, C. Ponting
semanticscholar   +1 more source

Oxidatively damaged proteins of heart mitochondrial electron transport complexes

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2004
Protein modifications, such as carbonylation, nitration and formation of lipid peroxidation adducts, e.g. 4-hydroxynonenal (HNE), are products of oxidative damage attributed to reactive oxygen species (ROS). The mitochondrial respiratory chain Complexes I and III have been shown to be a major source of ROS in vitro.
Choksi, K.B., Boylston, W.H., Rabek, J.P., Widger, W.R., Papaconstantinou, J.   +4 more
openaire   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Protection Against Cardiac Injury by Small Ca\u3csup\u3e2 +\u3c/sup\u3e-Sensitive K\u3csup\u3e+\u3c/sup\u3e Channels Identified in Guinea Pig Cardiac Inner Mitochondrial Membrane [PDF]

, 2013
We tested if small conductance, Ca2 +‐sensitive K+ channels (SKCa) precondition hearts against ischemia reperfusion (IR) injury by improving mitochondrial (m) bioenergetics, if O2‐derived free radicals are required to initiate protection via SKCa ...
Aldakkak, Mohammed, Camara, Amadou K.S., Cheng, Qunli, Gadicherla, Ashish K., Heisner, James S., Jiang, Ming Tao, Kwok, Wai-Meng, Stowe, David F., Yang, MeiYing, Zhou, Yifan   +9 more
core   +1 more source