Results 11 to 20 of about 495,836 (314)

Lipophilic triphenylphosphonium cations inhibit mitochondrial electron transport chain and induce mitochondrial proton leak. [PDF]

PLoS ONE, 2015
The lipophilic positively charged moiety of triphenylphosphonium (TPP+) has been used to target a range of biologically active compounds including antioxidants, spin-traps and other probes into mitochondria.
Jan Trnka, Moustafa Elkalaf, Michal Anděl   +2 more
doaj   +5 more sources

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease. [PDF]

Sci Rep, 2019
Multiple system atrophy (MSA) is a neurodegenerative disease characterised by glial cytoplasmic inclusions (GCIs), containing α-synuclein. Mutated COQ2, encoding an enzyme essential for co-enzyme Q10 (CoQ10) biosynthesis, has been associated with MSA ...
Foti SC, Hargreaves I, Carrington S, Kiely AP, Houlden H, Holton JL.   +5 more
europepmc   +2 more sources

Physiologic Implications of Reactive Oxygen Species Production by Mitochondrial Complex I Reverse Electron Transport

Antioxidants, 2019
Mitochondrial reactive oxygen species (ROS) can be either detrimental or beneficial depending on the amount, duration, and location of their production.
John O. Onukwufor, Brandon J. Berry, Andrew P. Wojtovich   +2 more
doaj   +2 more sources

Respiratory electron transfer pathways in plant mitochondria [PDF]

Frontiers in Plant Science, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Peter eSchertl, Hans-Peter eBraun
doaj   +5 more sources

Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis. [PDF]

Int J Biochem Cell Biol, 2020
Kalpage HA, Wan J, Morse PT, Zurek MP, Turner AA, Khobeir A, Yazdi N, Hakim L, Liu J, Vaishnav A, Sanderson TH, Recanati MA, Grossman LI, Lee I, Edwards BFP, Hüttemann M.   +15 more
europepmc   +2 more sources

A potassium channel β-subunit couples mitochondrial electron transport to sleep. [PDF]

Nature, 2019
Kempf A, Song SM, Talbot CB, Miesenböck G.   +3 more
europepmc   +2 more sources

Mechanisms and mathematical modelling of ROS production by the mitochondrial electron transport chain.

American Journal of Physiology - Cell Physiology, 2022
Reactive oxygen species (ROS) are recognised both as damaging molecules and intracellular signalling entities. In addition to its role in ATP generation, the mitochondrial electron transport chain (ETC) constitutes a relevant source of mitochondrial ROS,
Sandeep Chenna, W. Koopman, J. Prehn, N. Connolly   +3 more
semanticscholar   +1 more source

Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload‐Induced Right Ventricular Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition from
HyunTae V. Hwang, Nefthi Sandeep, Ramesh V. Nair, Dong‐Qing Hu, Mingming Zhao, Ingrid S. Lan, Giovanni Fajardo, Scot J. Matkovich, Daniel Bernstein, Sushma Reddy   +9 more
doaj   +1 more source

A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity. [PDF]

PLoS Computational Biology, 2016
The clinical use of the anthracycline doxorubicin is limited by its cardiotoxicity which is associated with mitochondrial dysfunction. Redox cycling, mitochondrial DNA damage and electron transport chain inhibition have been identified as potential ...
Bernardo L de Oliveira, Steven Niederer
doaj   +1 more source

Analysis of mitochondrial respiration and ATP synthase in frozen brain tissues

Heliyon, 2023
Studying mitochondrial respiration capacity is essential for gaining insights into mitochondrial functions. In frozen tissue samples, however, our ability to study mitochondrial respiration is restricted by damage elicited to the inner mitochondrial ...
Pamela J. Yao, Rachel Munk, Myriam Gorospe, Dimitrios Kapogiannis   +3 more
doaj   +1 more source