Results 271 to 280 of about 495,836 (314)

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

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Regulation of Mitochondrial Electron Transport Chain Assembly.

Journal of Molecular Biology, 2018
Mitochondrial function depends on the correct synthesis, transport, and assembly of proteins and cofactors of the electron transport chain. The initial idea that the respiratory chain protein complexes (RCCs) were independent structures in the inner mitochondrial membrane evolved after the identification of higher quaternary structures called ...
S. Cogliati, I. Lorenzi, Giovanni Rigoni, F. Caicci, M. Soriano   +4 more
semanticscholar   +4 more sources

The mitochondrial electron transport and oxidative phosphorylation system.

Annual Review of Biochemistry, 1985
NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) . . ....... .. .... . . . . . . . . . . . . . . . . 1019 Compositio, of Complex I 1019 Light Absorption and ESR Spectral Properties of Complex I . ... ......... 1020 Structure of Complex I 1022 Catalytic Properties and Mechanism of Action of Complex I 1022 SUCCINATE:UBIQUINONE OXIDOREDUCTASE (COMPLEX II) .
Y. Hatefi
semanticscholar   +3 more sources

Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain

Science, 2013
Respiration Refined Cells derive energy from redox reactions mediated by mitochondrial enzymes that form the electron transport chain. The enzymes can form large complexes, known as supercomplexes, whose function has been controversial. Lapuente-Brun et al. (p.
Esther Lapuente-Brun, Esther Lapuente-Brun, R. Moreno-Loshuertos, R. Acín-Pérez, Ana Latorre-Pellicer, C. Colás, E. Balsa, E. Balsa, Ester Perales-Clemente, Pedro M. Quirós, E. Calvo, M. A. Rodríguez-Hernández, P. Navas, R. Cruz, Á. Carracedo, C. López-Otín, A. Pérez-Martos, P. Fernández-Silva, E. Fernández‐Vizarra, J. Enríquez, J. Enríquez   +20 more
semanticscholar   +5 more sources

Impairment of mitochondrial electron transport by tetrachloroethylene

Toxicology Letters, 1983
Impairment of electron transport was studied in rat liver sonicated submitochondrial particles. The most susceptible portion was located from NADH dehydrogenase to coenzyme Q. Tetrachloroethylene increased the Michaelis constant (Km) and decreased the maximum velocity (Vmax) of cytochrome c reduction by NADH-cytochrome c reductase.
Y, Miyazaki, T, Takano
openaire   +2 more sources

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

Archives of Biochemistry and Biophysics, 1994
Mammalian mitochondria are sensitive targets of the cytotoxic effects of superoxide (O.2-) and nitric oxide (.NO). In turn, when superoxide and nitric oxide are simultaneously produced, they rapidly react with each other yielding the highly oxidizing peroxynitrite anion (ONOO-) which may be also toxic to mammalian mitochondria.
R, Radi, M, Rodriguez, L, Castro, R, Telleri   +3 more
openaire   +2 more sources