Results 21 to 30 of about 495,836 (314)

TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

Science, 2022
Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necrosis
F. J. Roca, Laura J. Whitworth, H. Prag, Michael P. Murphy, L. Ramakrishnan   +4 more
semanticscholar   +1 more source

Mitochondrial protein synthesis and the bioenergetic cost of neurodevelopment

iScience, 2022
Summary: The human brain consumes five orders of magnitude more energy than the sun by unit of mass and time. This staggering bioenergetic cost serves mostly synaptic transmission and actin cytoskeleton dynamics.
Pernille Bülow, Anupam Patgiri, Victor Faundez   +2 more
doaj   +1 more source

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

Frontiers in Molecular Neuroscience, 2021
Parkinson’s disease (PD) is known as a mitochondrial disease. Some even regarded it specifically as a disorder of the complex I of the electron transport chain (ETC).
Jeng-Lin Li, Tai-Yi Lin, Po-Lin Chen, Ting-Ni Guo, Shu-Yi Huang, Chun-Hong Chen, Chin-Hsien Lin, Chih-Chiang Chan   +7 more
semanticscholar   +1 more source

Mitochondrial biogenesis drives a vicious cycle of metabolic insufficiency and mitochondrial DNA deletion mutation accumulation in aged rat skeletal muscle fibers. [PDF]

PLoS ONE, 2013
Aged muscles possess dysfunctional fibers that contain intracellular expansions of somatically derived mitochondrial DNA deletion mutations. At high abundance, these mutations disrupt the expression of mitochondrially-encoded protein subunits of the ...
Allen Herbst, Chad J Johnson, Kayla Hynes, Debbie McKenzie, Judd M Aiken   +4 more
doaj   +1 more source

ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury

Nature Communications, 2023
Mitochondria dysfunction contributes to acute liver injuries, and mitochondrial regulators, such as PGC-1α and MCJ, affect liver regeneration. Therefore, identification of mitochondrial modulators may pave the way for developing therapeutic strategies ...
Yankun Zhang, Yuchen Fan, Huili Hu, Xiaohui Zhang, Zehua Wang, Zhuanchang Wu, Liyuan Wang, Xiangguo Yu, Xiaojia Song, Peng Xiang, Xiaodong Zhang, Tixiao Wang, Siyu Tan, Chunyang Li, Lifen Gao, Xiaohong Liang, Shuijie Li, Nailin Li, Xuetian Yue, Chunhong Ma   +19 more
doaj   +1 more source

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

BMC Research Notes, 2011
The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
doaj   +1 more source

Mitochondrial electron transport activity and metabolism of experimentally bleached hermatypic corals [PDF]

, 2016
Bleached corals (Porites cylindrica and Galaxea fascicularis) were obtained through extended incubation (over 45 days) under light depletion and privation: low light and dark conditions, and heat stress (32 °C).
Fujimura Hiroyuki, Fujita Kazuhiko, Hayashi Hiroyuki, アゴスティーニ シルバン   +3 more
core   +2 more sources

Endurance exercise training in pulmonary hypertension increases skeletal muscle electron transport chain supercomplex assembly

Pulmonary Circulation, 2020
Pulmonary hypertension is associated with pronounced exercise intolerance (decreased V ċ O 2 max) that can significantly impact quality of life. The cause of exercise intolerance in pulmonary hypertension remains unclear. Mitochondrial supercomplexes are
Danielle J. McCullough, Nouaying Kue, Thomas Mancini, Alexander Vang, Richard T. Clements, Gaurav Choudhary   +5 more
doaj   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in Mice. [PDF]

PLoS ONE, 2017
The vitamin B12 analog hydroxy-cobalamin[c-lactam] (HCCL) impairs hepatic mitochondrial protein synthesis and function of the electron transport chain in rats.
Patrizia Haegler, David Grünig, Benjamin Berger, Luigi Terracciano, Stephan Krähenbühl, Jamal Bouitbir   +5 more
doaj   +1 more source