Results 41 to 50 of about 495,836 (314)

Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]

, 2013
Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C, Gonzalez, Reyna, Hofman, Florence M, Louie, Stan G, Pao, Peng-Wen, Pirrung, Michael C, Schönthal, Axel H, Sharma, Natasha, Thomas, Simmy   +8 more
core   +2 more sources

Transport of proteins into mitochondria [PDF]

, 1985
Translocational intermediates of precursor proteins of ATPase F1β subunit and cytochrome c1 across mitochondrial membranes were analyzed using two different approaches, transport at low temperature and transport after binding of precursor proteins to ...
Neupert, Walter, Schleyer, Manfred
core   +1 more source

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain*

Journal of Biological Chemistry, 2002
We measured production of reactive oxygen species by intact mitochondria from rat skeletal muscle, heart, and liver under various experimental conditions.
J. St-Pierre, Julie A. Buckingham, Stephen J Roebuck, M. Brand   +3 more
semanticscholar   +1 more source

Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction [PDF]

BioFactors, 2012
AbstractMitochondrial dysfunction (primary or secondary) is detrimental to intermediary metabolism. Therapeutic strategies to treat/prevent mitochondrial dysfunction could be valuable for managing metabolic and age‐related disorders. Here, we review strategies proposed to treat mitochondrial impairment.
Hani, Atamna, Jeanette, Mackey, Joseph M, Dhahbi   +2 more
openaire   +2 more sources

Regulation of the Stress-Activated Degradation of Mitochondrial Respiratory Complexes in Yeast

Frontiers in Microbiology, 2018
Repair and removal of damaged mitochondria is a key process for eukaryotic cell homeostasis. Here we investigate in the yeast model how different protein complexes of the mitochondrial electron transport chain are subject to specific degradation upon ...
Alba Timón-Gómez, Alba Timón-Gómez, David Sanfeliu-Redondo, Amparo Pascual-Ahuir, Markus Proft   +4 more
doaj   +1 more source

Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo. [PDF]

PLoS ONE, 2009
Mutations in mitochondrial DNA polymerase (pol gamma) cause several progressive human diseases including Parkinson's disease, Alper's syndrome, and progressive external ophthalmoplegia. At the cellular level, disruption of pol gamma leads to depletion of
Rehan M Baqri, Brittany A Turner, Mary B Rheuben, Bradley D Hammond, Laurie S Kaguni, Kyle E Miller   +5 more
doaj   +1 more source

Mitochondrial Complex Abundance, Mitophagy Proteins, and Physical Performance in People With and Without Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Mitochondrial abnormalities exist in gastrocnemius muscle of people with peripheral artery disease (PAD). Whether abnormalities in mitochondrial biogenesis and autophagy are associated with greater ischemia or walking impairment in PAD is ...
Anna Picca, Stephanie E. Wohlgemuth, Mary M. McDermott, Sunil K. Saini, Sudarshan Dayanidhi, Dongxue Zhang, Shujun Xu, Kate Kosmac, Lu Tian, Luigi Ferrucci, Robert L. Sufit, Emanuele Marzetti, Christiaan Leeuwenburgh   +12 more
doaj   +1 more source

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria [PDF]

, 2006
Arabidopsis thaliana mutants prors1-1 and -2 were identified on the basis of a decrease in effective photosystem II quantum yield. Mutations were localized to the 5'-untranslated region of the nuclear gene PROLYL-tRNA SYNTHETASE1 (PRORS1), which acts in ...
Bhushan, Shashi, Braun, Hans-Peter, Eubel, Holger, Glaser, Elzbieta, Leister, Dario, Masiero, Simona, Pesaresi, Paolo, Salamini, Francesco   +7 more
core   +2 more sources

Mitochondrial electron transport-linked tocopheroxyl radical reduction

Journal of Biological Chemistry, 1989
alpha-Tocopherol (vitamin E) is a lipophilic chain-breaking antioxidant which inhibits lipid peroxidation in isolated mitochondrial membranes and protects membranes from oxidative damage. The primary oxidation product of vitamin E is the tocopheroxyl radical.
J J, Maguire, D S, Wilson, L, Packer
openaire   +2 more sources

The combination of endurance exercise and SGTC (Salvia–Ginseng–Trigonella–Cinnamon) ameliorate mitochondrial markers’ overexpression with sufficient ATP production in the skeletal muscle of mice fed AGEs-rich high-fat diet

Nutrition & Metabolism, 2022
Background Skeletal muscle mitochondria is one of the most important affected sites of T2DM and its molecular mechanism is yet to be elucidated. Some recent theories believed that mitochondrial markers are upregulated in response to high fat induced T2DM;
Maryam Haghparast Azad, Iman Niktab, Shaghayegh Dastjerdi, Navid Abedpoor, Golbarg Rahimi, Zahra Safaeinejad, Maryam Peymani, Farzad Seyed Forootan, Majid Asadi-Shekaari, Mohammad Hossein Nasr Esfahani, Kamran Ghaedi   +10 more
doaj   +1 more source