Results 51 to 60 of about 495,836 (314)
Status of Mitochondrial Oxidative Phosphorylation during the Development of Heart Failure
Antioxidants, 2023 Mitochondria are specialized organelles, which serve as the “Power House” to generate energy for maintaining heart function. These organelles contain various enzymes for the oxidation of different substrates as well as the electron transport chain in the
Sukhwinder K. Bhullar +1 more
doaj +1 more source
New Phytologist, 2019 •Hypoxia regularly occurs during plant development and can be induced by the environment, for example through flooding. •To understand how plant tissue physiology responds to progressing oxygen restriction, we aimed at monitoring subcellular physiology ...
Stephan Wagner +12 more
semanticscholar +1 more source
Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]
, 2006 The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial ...
Abdul +39 more
core +4 more sources
Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function
Biomolecules, 2018 Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of action remains a mystery. It is well known for regulating mitochondrial function and coupling of the electron transport chain and ATP synthesis by controlling the ...
George A. Porter, Gisela Beutner
doaj +1 more source
Nature Neuroscience, 2019 Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2).
Steven M. Graves +13 more
semanticscholar +1 more source
Manipulating mitochondrial electron flow enhances tumor immunogenicity
Science, 2023 Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In this work, we report that the loss of CII,
K. Mangalhara +20 more
semanticscholar +1 more source
Frataxin interacts functionally with mitochondrial electron transport chain proteins [PDF]
Human Molecular Genetics, 2005 Frataxin deficiency is the main cause of Friedreich ataxia, an autosomal recessive neurodegenerative disorder. Frataxin function in mitochondria has not been fully explained yet. In this work, we show that Saccharomyces cerevisiae frataxin orthologue Yfh1p interacts physically with succinate dehydrogenase complex subunits Sdh1p and Sdh2p of the yeast ...
Pilar, González-Cabo +4 more
openaire +2 more sources
Global Challenges, 2018 A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found.
Jinhua Li +6 more
semanticscholar +1 more source
Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production
AntioxidantsOne of the major causes of senescence is oxidative stress caused by ROS, which is mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective ...
Myeong Uk Kuk +12 more
doaj +1 more source
Common Mitochondrial DNA Mutations Generated through DNA-Mediated Charge Transport [PDF]
, 2009 Mutation sites that arise in human mitochondrial DNA as a result of oxidation by a rhodium photooxidant have been identified. HeLa cells were incubated with [Rh(phi)2bpy]Cl3 (phi is 9,10-phenanthrenequinone diimine), an intercalating photooxidant, to ...
Barton, Jacqueline K. +2 more
core +2 more sources