Results 81 to 90 of about 495,836 (314)

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan [PDF]

Cell Metabolism, 2016
Increased production of reactive oxygen species (ROS) has long been considered a cause of aging. However, recent studies have implicated ROS as essential secondary messengers. Here we show that the site of ROS production significantly contributes to their apparent dual nature. We report that ROS increase with age as mitochondrial function deteriorates.
Filippo Scialó, A. Sriram, Daniel J M Fernández-Ayala, N. Gubina, M. Lōhmus, G. Nelson, A. Logan, H. Cooper, P. Navas, J. Enríquez, M. Murphy, A. Sanz   +11 more
semanticscholar   +8 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Complementary Roles of Chloroplast Cyclic Electron Transport and Mitochondrial Alternative Oxidase to Ensure Photosynthetic Performance

Frontiers in Plant Science, 2021
Chloroplasts use light energy and a linear electron transport (LET) pathway for the coupled generation of NADPH and ATP. It is widely accepted that the production ratio of ATP to NADPH is usually less than required to fulfill the energetic needs of the ...
Avesh Chadee, Nicole A. Alber, Keshav Dahal, Greg C. Vanlerberghe   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

Parkinson's Disease, 2016
Peroxisome proliferator-activated receptor  γ coactivator 1α (PGC-1α) is a central regulator of cellular and mitochondrial metabolism. Cellular bioenergetics are critically important in “energy-guzzling” neurons, but the components and wiring of the ...
Rachit Bakshi, Shuchi Mittal, Zhixiang Liao, Clemens R. Scherzer   +3 more
doaj   +1 more source

Mitochondrial Iron Metabolism: The Crucial Actors in Diseases

Molecules, 2022
Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to ...
Geyan Duan, Jianjun Li, Yehui Duan, Changbing Zheng, Qiuping Guo, Fengna Li, Jie Zheng, Jiayi Yu, Peiwen Zhang, Mengliao Wan, Cimin Long   +10 more
doaj   +1 more source

Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease

Frontiers in Physiology, 2017
Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to be the main cause of aging and age-related diseases including cancer, diabetes and Parkinson's disease.
Filippo Scialó, Daniel J M Fernández-Ayala, A. Sanz   +2 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Mitochondria in Embryogenesis: An Organellogenesis Perspective

Frontiers in Cell and Developmental Biology, 2019
Organogenesis is well characterized in vertebrates. However, the anatomical and functional development of intracellular compartments during this phase of development remains unknown.
Yoan Arribat, Dogan Grepper, Sylviane Lagarrigue, Joy Richard, Mélanie Gachet, Philipp Gut, Francesca Amati   +6 more
doaj   +1 more source

Residual mitochondrial transmembrane potential decreases unsaturated fatty acid level in sake yeast during alcoholic fermentation [PDF]

PeerJ, 2016
Oxygen, a key nutrient in alcoholic fermentation, is rapidly depleted during this process. Several pathways of oxygen utilization have been reported in the yeast Saccharomyces cerevisiae during alcoholic fermentation, namely synthesis of unsaturated ...
Kazutaka Sawada, Hiroshi Kitagaki
doaj   +2 more sources