Results 221 to 230 of about 528,538 (308)

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

open access: yesAdvanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang   +12 more
wiley   +1 more source

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine‐dependent Tumor Subset Under Metabolic Relationships With CAFs.

open access: yesAdvanced Science, EarlyView.
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Sauyeun Shin   +25 more
wiley   +1 more source

The complete mitochondrial genome of <i>Psyllaephagus populi</i> (Hymenoptera: Encyrtidae). [PDF]

open access: yesMitochondrial DNA B Resour
Aishan Z   +4 more
europepmc   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

open access: yesAdvanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He   +8 more
wiley   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

open access: yesAdvanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying   +8 more
wiley   +1 more source

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