Results 221 to 230 of about 1,901,465 (382)

Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer’s disease [PDF]

, 1999
Sayaka Ito, Shigeo Ohta, Kiyomi Nishimaki, Yasuo Kagawa, Rika Soma, Shinya Kuno, Yasuko Komatsuzaki, Hidehiro Mizusawa, Jun‐Ichi Hayashi   +8 more
openalex   +1 more source

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan, Elodie Roger, Lukas Perkhofer, Eleni Zimmer, Thomas F.E. Barth, Julia P. Mosler, Anna Härle, Stephanie E. Weissinger, Nadine T. Gaisa, Peter Möller, Nico Fischer, Chantal Allgöwer, J.‐Matthias Löhr, Dirk Grimm, Thomas Seufferlein, Stefan Liebau, Ninel Azoitei, Michael K. Melzer, Frank Arnold, Johann Gout, Alexander Kleger   +20 more
wiley   +1 more source

Phylogenetic position and mitochondrial genome evolution of "orphan" eukaryotic lineages. [PDF]

iScience
Zlatogursky V, Boscaro V, Lax G, Wanntorp M, Pohl N, Burki F, Keeling PJ.   +6 more
europepmc   +2 more sources

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Abundance of Maternal Mitochondrial Genome Is Dispensable up to the Mitochondrial Genome Activation in Post-Implantation Embryos. [PDF]

FASEB J
Shavit M, Vancová M, Jedlicka J, Bílý T, Mahrouk M, Cendelin J, Grygarova K, Popelková K, Tůma Z, Pribanova G, Kuncová J, Nevoral J.   +11 more
europepmc   +1 more source

Contribution of Ultra-Short Invasive Elements to the Evolution of the Mitochondrial Genome in the Genus Podospora [PDF]

, 1996
France Koll, J. Boulay, L. Belcour, Yves d’Aubenton-Carafa   +3 more
openalex   +1 more source

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, EarlyView.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source

Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments

Proceedings of the National Academy of Sciences of the United States of America, 2013
Jesse Dabney, M. Knapp, Isabelle Glocke, Marie-Theres Gansauge, A. Weihmann, B. Nickel, Cristina E. Valdiosera, N. García, S. Pääbo, J. Arsuaga, M. Meyer   +10 more
semanticscholar   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Complete mitochondrial genome of <i>Mycena pura</i> (Mycenaceae, Agaricales). [PDF]

Mitochondrial DNA B Resour
Na JL, Zhang YJ, Zhang S.
europepmc   +1 more source