Results 251 to 260 of about 328,957 (317)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

The complete mitochondrial genome of <i>Fusicolla acetilerea</i> (Nectriaceae, Hypocreales). [PDF]

Mitochondrial DNA B Resour
Cha Y, You YH, Lee SY, Jung HY, Kim C, Oh SY.   +5 more
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

The Complete Mitochondrial Genome of <i>Conopomorpha sinensis</i> (Lepidoptera: Gracillariidae) Sample from Taiwan. [PDF]

Genes (Basel)
Kuo YY, Wang TC, Chen PC, Chang J, Nai YS.   +4 more
europepmc   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Towards CRISPR-based editing of the mitochondrial genome in yeast. [PDF]

Proc Natl Acad Sci U S A
Yin S, Jarosz DF, Ting AY.
europepmc   +1 more source

Phylogenetic Relationships of Five Phallales Species Based on Mitochondrial Genome Analysis. [PDF]

J Fungi (Basel)
Wang Y, Li D, Wang G, Guo Z, Wang X, Liu H.   +5 more
europepmc   +1 more source

Mitochondrial genome of Iodes seguinii reveals repeat-mediated recombination and phylogenetic insights in Icacinaceae. [PDF]

BMC Genomics
Yu S, Wang M, Gong X, Qin M, Tang M.
europepmc   +1 more source