Results 31 to 40 of about 1,901,465 (382)

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]

, 2018
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés, Pérez de Camino Cantos, Dolores, Silva, Sonia   +2 more
core   +1 more source

Characterization of the complete mitochondrial genome of Sterigmatomyces hyphaenes (Agaricostilbales: Agaricostilbaceae) and implications for its phylogeny

Mitochondrial DNA. Part B. Resources, 2020
In this study, the complete mitochondrial genome of Sterigmatomyces hyphaenes was sequenced by the next-generation sequencing. The complete mitochondrial genome of S. hyphaenes contained 17 protein-coding genes (PCG), 2 ribosomal RNA (rRNA) genes, and 23
Maoling Tan, Qiangfeng Wang
doaj   +1 more source

The mitochondrial genome of Cavia aperea [PDF]

Mitochondrial DNA Part B, 2020
Cavia aperea is a wild guinea pig found throughout South America. The previously published mitochondrial sequence for C. aperea was highly divergent from the C. porcellus sequence and contained stop codons within open reading frames. Here we resequenced the mitochondrial genomes of C. aperea and C. porcellus.
Azizia Wahedi, Anja Günther, Alexandra Weyrich, Neal Sondheimer   +3 more
openaire   +6 more sources

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

Nature Communications, 2019
The role of mitochondrial DNA mutations in organismal fitness and lifespan have been studied in mitochondrial mutator models with varying results. Here, the authors generate a new APOBEC1 expression-based Drosophila mutator model and show that it has ...
Simonetta Andreazza, Colby L. Samstag, Alvaro Sanchez-Martinez, Erika Fernandez-Vizarra, Aurora Gomez-Duran, Juliette J. Lee, Roberta Tufi, Michael J. Hipp, Elizabeth K. Schmidt, Thomas J. Nicholls, Payam A. Gammage, Patrick F. Chinnery, Michal Minczuk, Leo J. Pallanck, Scott R. Kennedy, Alexander J. Whitworth   +15 more
doaj   +1 more source

Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels [PDF]

, 2001
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these ...
Benne R., Beverley S.M., Brun R., Carruthers V.B., Czichos J., Feagin J.E., Folsch H., Hahne K., Hauser R., Hausler T., Hirumi H., Kwast K.E., LeBowitz J.H., Matthews K.R., Osinga K.A., Overath P., Priest J.W., Roditi I., Sherwin T., Smagula C., Sogin M.L., Stuart K., Tasker M., Torri A.F., Tschudi C., Ullu E., Vassella E., Wirtz E., Woods A., Ziegelbauer K.   +29 more
core   +1 more source

Editing the Mitochondrial Genome

New England Journal of Medicine, 2020
Mending Mitochondrial Mutation For most patients with mitochondrial disorders, most of which are caused by mutations in genes in the mitochondrial genome, only symptomatic treatment is available.
Maria Falkenberg, Michio Hirano
openaire   +3 more sources

Plant genetic reseources: effective utilization [PDF]

, 2010
Characterizing better understanding the genome organization and differentiating identity of genotypes based on their morphology and genome characteristics are vital determinants in their commercialization, management of germplasm repositories, and ...
Budak, Hikmet
core   +1 more source

The complete mitochondrial genome of Xenopsylla cheopis (Siphonaptera: Pulicidae)

Mitochondrial DNA. Part B. Resources, 2022
Xenopsylla cheopis, also called oriental rat flea, is an ectoparasite as well as disease vector for murine typhus and bubonic plague. In the study, the whole mitochondrial genome of X.
Furong Wei, Xiaokai Jia, Ying Wang, Yuetao Yang, Junyun Wang, Chunhua Gao, Yong Wang   +6 more
doaj   +1 more source

A fragmented metazoan organellar genome [PDF]

, 2008
Background: Animal mitochondrial (mt) genomes are characteristically circular molecules of ~16–20 kb. Medusozoa (Cnidaria excluding Anthozoa) are exceptional in that their mt genomes are linear and sometimes subdivided into two to presumably four ...
Erpenbeck, Dirk, Voigt, Oliver, Wörheide, Gert   +2 more
core   +1 more source

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

Nature Communications, 2016
The post-transcriptional 5-methylcytosine (m5C) modification occurs in a wide range of nuclear-encoded RNAs. Here the authors identify the mitochondrial tRNA-Met as a target for the m5C methyltransferase NSun3—found mutated in a mitochondrial disease ...
Lindsey Van Haute, Sabine Dietmann, Laura Kremer, Shobbir Hussain, Sarah F. Pearce, Christopher A. Powell, Joanna Rorbach, Rebecca Lantaff, Sandra Blanco, Sascha Sauer, Urania Kotzaeridou, Georg F. Hoffmann, Yasin Memari, Anja Kolb-Kokocinski, Richard Durbin, Johannes A. Mayr, Michaela Frye, Holger Prokisch, Michal Minczuk   +18 more
doaj   +1 more source