Results 51 to 60 of about 1,479,322 (313)

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

open access: yesCell Reports
Summary: Mitochondrial calcium (Ca2+) uptake augments metabolic processes and buffers cytosolic Ca2+ levels; however, excessive mitochondrial Ca2+ can cause cell death.
Madeleine J. Twyning   +9 more
doaj   +1 more source

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. [PDF]

open access: yes, 2015
Two key biological features distinguish Trypanosoma evansi from the T. brucei group: independence from the tsetse fly as obligatory vector, and independence from the need for functional mitochondrial DNA (kinetoplast or kDNA).
Hideo Imamura (62469)   +112 more
core   +1 more source

Mitochondrial Genome Variants as a Cause of Mitochondrial Cardiomyopathy

open access: yesCells, 2022
Mitochondria are small double-membraned organelles responsible for the generation of energy used in the body in the form of ATP. Mitochondria are unique in that they contain their own circular mitochondrial genome termed mtDNA. mtDNA codes for 37 genes, and together with the nuclear genome (nDNA), dictate mitochondrial structure and function.
Teresa Campbell   +2 more
openaire   +5 more sources

De novo assembly of the complete mitochondrial genome of sweet potato (Ipomoea batatas [L.] Lam) revealed the existence of homologous conformations generated by the repeat-mediated recombination

open access: yesBMC Plant Biology, 2022
Sweet potato (Ipomoea batatas [L.] Lam) is an important food crop, an excellent fodder crop, and a new type of industrial raw material crop. The lack of genomic resources could affect the process of industrialization of sweet potato. Few detailed reports
Zhijian Yang   +7 more
doaj   +1 more source

Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome [PDF]

open access: yesOxidative Medicine and Cellular Longevity, 2017
Mitochondria preserve very complex and distinctively unique machinery to maintain and express the content of mitochondrial DNA (mtDNA). Similar to chromosomes, mtDNA is packaged into discrete mtDNA‐protein complexes referred to as a nucleoid. In addition to its role as a mtDNA shield, over 50 nucleoid‐associated proteins play roles in mtDNA maintenance
Sung Ryul Lee, Jin Han
openaire   +2 more sources

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

open access: yes, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter   +10 more
core   +1 more source

Screening for the ancient polar bear mitochondrial genome reveals low integration of mitochondrial pseudogenes (numts) in bears

open access: yesMitochondrial DNA. Part B. Resources, 2017
Phylogenetic analyses of nuclear and mitochondrial genomes indicate that polar bears captured the brown bear mitochondrial genome 160,000 years ago, leading to an extinction of the original polar bear mitochondrial genome.
Fritjof Lammers   +4 more
doaj   +1 more source

Genome Editing of Plant Mitochondrial and Chloroplast Genomes

open access: yesPlant And Cell Physiology, 2023
Abstract Plastids (including chloroplasts) and mitochondria are remnants of endosymbiotic bacteria, yet they maintain their own genomes, which encode vital components for photosynthesis and respiration, respectively. Organellar genomes have distinctive features, such as being present as multicopies, being mostly inherited maternally ...
Shin-ichi Arimura, Issei Nakazato
openaire   +2 more sources

Human mitochondrial transcription and translation

open access: yes, 2020
The maintenance and expression of the mammalian mitochondrial genome (mtDNA) is a fundamental aspect of mitochondrial biogenesis. The mtDNA is transcribed as precursor polycistronic transcripts containing 11 mRNAs, 2 rRNAs, punctuated by 22 tRNAs.
Agnel Sfeir   +9 more
core   +1 more source

The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity [PDF]

open access: yes, 2012
Overexpression or mutation of alpha-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function.
Butler, Erin K.   +41 more
core   +2 more sources

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